Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast.
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APG9L2 (ATG9B) is placenta- and pituitary-enriched.
"In human adult tissues, APG9L1 was ubiquitously expressed, whereas APG9L2 was highly expressed in placenta (trophoblast cells) and pituitary gland."
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APG9L2 complements APG9L1 in autophagosome formation.
"In addition, APG9L2 can functionally complement APG9L1 in this process."
Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.
ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A.
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ATG9B is a homotrimeric lipid scramblase.
"Consistent with the experimental structure and computational chemistry, we establish that ATG9B is a functional lipid scramblase."
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ATG9B compensates for ATG9A loss.
"We show that ATG9B can compensate for the absence of ATG9A in starvation-induced autophagy displaying similar subcellular trafficking and steady-state localization."
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ATG9B localizes to Golgi and endosomes.
"Like ATG9A, ATG9B was mainly co-localized with the Golgi marker GOLGA2/GM130, to a lesser extent with early endosomes, positive for EEA1, and recycling endosomes labeled using RAB11 (Figure 6A)."
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ATG9B binds ATG2A.
"Finally, we demonstrate that ATG9B can form a heteromeric complex with ATG2A."
UniProt entry Q674R7 (ATG9B_HUMAN)
Affinage mechanistic annotation for ATG9B (human)