Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex.
MAD2B is an inhibitor of the anaphase-promoting complex.
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1).
Mitotic degradation of human thymidine kinase 1 is dependent on the anaphase-promoting complex/cyclosome-CDH1-mediated pathway.
The anaphase-promoting complex: a key factor in the regulation of cell cycle.
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.
A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.
Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress.
Hypoxia and cell cycle regulation of the von Hippel-Lindau tumor suppressor.
Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.
Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1.
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.
Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.
Acetylation-dependent regulation of Skp2 function.
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex.
The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.
Molecular mechanism of APC/C activation by mitotic phosphorylation.
APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry.
CCDC84 Acetylation Oscillation Regulates Centrosome Duplication by Modulating HsSAS-6 Degradation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
De novo FZR1 loss-of-function variants cause developmental and epileptic encephalopathies.
Multimodal cell maps as a foundation for structural and functional genomics.
Multiubiquitination of APC/C-associated Cdh1
Degradation of multiubiquitinated Cdh1
Association of Cdh1 with the APC/C
Phosphorylation of Cdh1 by Cyclin A:Cdk2
Association of cell cycle proteins with the APC/C:Cdh1 complex
Association of Emi1 with Cdh1
Degradation of multiubiquitinated cell cycle proteins
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
Dephosphorylation of phospho-Cdh1
Dissociation of phospho-Cdh1 from the APC/C complex
Ubiquitination of Emi1 by SCF-beta-TrCP
Phosphorylation of the Emi1 DSGxxS degron by Plk1
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex
SCF-mediated degradation of Emi1
Phosphorylated Emi1 binds the beta-TrCP in the SCF complex
Phosphorylation of Cdh1 by Cyclin B1:Cdc2
Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2
APC/C:Cdh1-mediated degradation of Skp2
Association of Cyclin A:Cdk2 with Cdh1
CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2
CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2
Cdh1:APC/C complex binds EHMT1:EHMT2
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
APC/C:Cdh1 polyubiquitinates SKP2
RB1 recruits APC/C:Cdh1 complex to SKP2
Defective RB1 does not form a complex with SKP2 and FZR1
CCNA:CDK1 phosphorylates FZR1
UniProtKB record for human FZR1 (Q9UM11)
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UniProt describes FZR1 as the substrate-specific adapter that associates with the APC/C in late mitosis, replacing CDC20, and activates it during anaphase and telophase; it is phosphorylated at G1/S and dissociates from the APC/C.
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Isoform 2 (major) is nuclear and isoform 3 (minor) is cytoplasmic; FZR1 is deacetylated by SIRT2 at Lys-69/Lys-159, dephosphorylated by CDC14B after DNA damage, and ubiquitinated by SCF(CCNF).
Falcon (Edison) deep-research report for human FZR1
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Synthesis describing FZR1 as the non-catalytic WD40 substrate receptor/coactivator of the APC/C active from late mitosis through G1 and in post-mitotic cells, with dynamic nuclear/chromatin and cytosolic localisation.
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Notes that some proposed neuronal APC/C-Cdh1 substrates were not confirmed when the core subunit APC4 was deleted, so FZR1-only phenotypes should not be assumed to reflect the ligase.