Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles.
Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets.
Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways.
Interaction of the RAGE cytoplasmic domain with diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42.
ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells.
Global landscape of HIV-human protein complexes.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous.
RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
RHOB:GTP recruits DIAPH1 or DIAPH3 to endosomes
MEMO1 binds RHOA:GTP:DIAPH1
Exocytosis of secretory granule membrane proteins
Exocytosis of ficolin-rich granule membrane proteins
RHOA binds effectors at the plasma membrane
RHOC binds effectors at the plasma membrane
RHOB binds effectors on endosomes
RHOF binds effectors at the plasma membrane
RHOD binds effectors at the plasma membrane
MITF-M-dependent DIAPH1 expression
Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans.
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.
Nuclear actin network assembly by formins regulates the SRF coactivator MAL.
Identification of Neurochondrin as a new interaction partner of the FH3 domain of the Diaphanous-related formin Dia1.
A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.
Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly.
The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons.
DIAPH1 evidence scope, source tracing and product boundaries
UniProt O60610 official DIAPH1 record