gcy-18 notes

Session 2026-10-08 (claude-code)

Deep research: just deep-research-falcon worm gcy-18 --fallback perplexity-lite failed
(falcon killed at the 600 s timeout; perplexity provider not available in this environment).
No deep-research file was created. Review based on cached publications in publications/,
the UniProt record, and GOA.

Annotation actions: {'MARK_AS_OVER_ANNOTATED': 1, 'ACCEPT': 20, 'REMOVE': 1, 'KEEP_AS_NON_CORE': 7}

Key evidence:
- AFD-specific; primary AFD cyclase at 20-25 C PMID:16415369
- Sets Tc memory/operating range; lowers T*AFD PMID:21315599
- Microvillar localization of thermosensory GCs requires BBS-8/DAF-25 PMID:25335890
- Protein kinase activity IEA REMOVED (pseudokinase); peptide receptor IBA over-annotated.