Use of the ND evidence code for Gene Ontology (GO) terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Molecular characterization of mammalian dicarbonyl/L-xylulose reductase and its localization in kidney.
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Purified mammalian DCXR proteins reduce alpha-dicarbonyls and interconvert xylitol and L-xylulose; this supports ortholog-based chemistry rather than a zebrafish assay.
"homotetramers with NADPH-linked reductase activity for alpha-dicarbonyl
compounds, catalyzed the oxidoreduction between xylitol and l-xylulose"
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The characterized L-xylulose reaction belongs to uronate metabolism, providing the basis for broad glucose-metabolism association.
"which is involved in the uronate cycle
of glucose metabolism"
DHS-21, a dicarbonyl/L-xylulose reductase (DCXR) ortholog, regulates longevity and reproduction in Caenorhabditis elegans.
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Recombinant C. elegans DHS-21, a PANTHER PTHR44252:SF3 member like zebrafish dcxr, reduces L-xylulose to xylitol with NADPH.
"Recombinant DHS-21 was shown to convert L-xylulose to xylitol using NADPH as a cofactor."
Bioinformatic and biochemical characterization of DCXR and DHRS2/4 from Caenorhabditis elegans.
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Substrate comparison with the human enzyme identifies C. elegans SDR20C18 (Q21929, dhs-21) as the DCXR ortholog.
"revealed that SDR20C18 is the DCXR-orthologue enzyme to the human enzyme"
C11orf54 catalyzes L-xylulose formation in human metabolism.
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DCXR acts in the pentose branch of D-glucuronate catabolism, reducing L-xylulose before SORD and XYLB produce D-xylulose-5-phosphate; the pathway is inferred to be ancestral in animals.
"L-xylulose is then converted into D-xylulose-5P by the subsequent action of L-xylulose reductase (DCXR), sorbitol dehydrogenase (SORD), and xylulokinase (XYLB)."
Cloning and sequence analysis of D-erythrulose reductase from chicken: its close structural relation to tetrameric carbonyl reductases.
Studies on D-tetrose metabolism. Crystallization and properties of D-erythrulose reductase from chicken liver.
Conservation of the DCXR catalytic site
dcxr re-review subfamily placement and catalytic-site conservation
UniProt record identifying the bacterial FabG function donor
Frozen exact-input ProtNLM output and UniProt sequence for Q567K5