Falcon deep research report for CDK2
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
GO annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
GO annotation based on curation of immunofluorescence data (HPA)
Automatic annotation by orthology (Ensembl Compara)
GO annotations based on automatic mapping of inter-ontology links (GOC)
GO annotation based on RHEA mapping of catalytic activity
Automatic annotation of UniProtKB entries (UniRule/ARBA)
Specificity of cyclin E-Cdk2, TFIIB, and E1A interactions with a common domain of the p300 coactivator.
Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression.
Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription.
Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2.
Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2.
Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation.
Human Speedy: a novel cell cycle regulator that enhances proliferation through activation of Cdk2.
Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor.
CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells.
Human Spy1 promotes survival of mammalian cells following DNA damage.
Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2.
DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes.
Cyclin A is required at two points in the human cell cycle.
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.
p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding.
Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.
NIRF induces G1 arrest and associates with Cdk2.
3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding.
Self-assembling protein microarrays.
N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2.
The crystal structure of human CDK7 and its protein recognition properties.
Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.
Cyclin E in normal and neoplastic cell cycles.
Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division.
Association of the human papillomavirus type 16 E7 oncoprotein with the 600-kDa retinoblastoma protein-associated factor, p600.
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.
Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells.
Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.
The nucleocapsid protein of severe acute respiratory syndrome-coronavirus inhibits the activity of cyclin-cyclin-dependent kinase complex and blocks S phase progression in mammalian cells.
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase.
Increased p21 expression and complex formation with cyclin E/CDK2 in retinoid-induced pre-B lymphoma cell apoptosis.
Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells.
C-terminal phosphorylation controls the stability and function of p27kip1.
Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.
p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2.
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.
SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression.
Role of intrinsic flexibility in signal transduction mediated by the cell cycle regulator, p27 Kip1.
Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17.
Cell cycle, CDKs and cancer: a changing paradigm.
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.
Identification and characterization of CAC1 as a novel CDK2-associated cullin.
Cdk2 nitrosylation and loss of mitochondrial potential mediate NO-dependent biphasic effect on HL-60 cell cycle.
Expanding the substantial interactome of NEMO using protein microarrays.
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis.
Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2.
HTLV-I p30 inhibits multiple S phase entry checkpoints, decreases cyclin E-CDK2 interactions and delays cell cycle progression.
Compartmentalized CDK2 is connected with SHP-1 and beta-catenin and regulates insulin internalization.
An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells.
Role of T198 modification in the regulation of p27(Kip1) protein stability and function.
Briefly bound to activate: transient binding of a second catalytic magnesium activates the structure and dynamics of CDK2 kinase for catalysis.
Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.
NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor.
Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.
The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme.
The stomatin-like protein SLP-1 and Cdk2 interact with the F-Box protein Fbw7-γ.
Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
The protein interaction landscape of the human CMGC kinase group.
Overexpression of DOC-1R inhibits cell cycle G1/S transition by repressing CDK2 expression and activation.
Foxp3 protein stability is regulated by cyclin-dependent kinase 2.
CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome.
Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.
CDK2-dependent phosphorylation of Suv39H1 is involved in control of heterochromatin replication during cell cycle progression.
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
A proteome-scale map of the human interactome network.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Regulation of Microtubule Assembly by Tau and not by Pin1.
NBS1 phosphorylation status dictates repair choice of dysfunctional telomeres.
Architecture of the human interactome defines protein communities and disease networks.
Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.
ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Maximizing binary interactome mapping with a minimal number of assays.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Multimodal cell maps as a foundation for structural and functional genomics.
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex.
Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2.
Structural and functional characterization of the HPV16 E7 protein expressed in bacteria.
In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.
Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex.
Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.
Structural basis of cyclin-dependent kinase activation by phosphorylation.
Cyclin-binding motifs are essential for the function of p21CIP1.
Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity.
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.