Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The small GTPase RalA targets filamin to induce filopodia.
Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA.
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit.
Prenylated Rab acceptor protein is a receptor for prenylated small GTPases.
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.
MgF(3)(-) as a transition state analog of phosphoryl transfer.
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution.
RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo.
A rho gene product in human blood platelets. I. Identification of the platelet substrate for botulinum C3 ADP-ribosyltransferase as rhoA protein.
Structural insights into the interaction of ROCKI with the switch regions of RhoA.
Inter-domain motions of the N-domain of the KdpFABC complex, a P-type ATPase, are not driven by ATP-induced conformational changes.
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle.
TIM, a Dbl-related protein, regulates cell shape and cytoskeletal organization in a Rho-dependent manner.
BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity.
An ECT2-centralspindlin complex regulates the localization and function of RhoA.
Towards a proteome-scale map of the human protein-protein interaction network.
The armadillo protein p0071 regulates Rho signalling during cytokinesis.
The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase.
Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets.
WGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulation.
Breast tumor kinase phosphorylates p190RhoGAP to regulate rho and ras and promote breast carcinoma growth, migration, and invasion.
Interaction of microglia and amyloid-beta through beta2-integrin is regulated by RhoA.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.
Regulation of mitotic spindle formation by the RhoA guanine nucleotide exchange factor ARHGEF10.
Speckled-like pattern in the germinal center (SLIP-GC), a nuclear GTPase expressed in activation-induced deaminase-expressing lymphomas and germinal center B cells.
Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.
Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase.
Activation of a bacterial virulence protein by the GTPase RhoA.
The Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migration.
Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration.
A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis.
Plk4 is required for cytokinesis and maintenance of chromosomal stability.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
The role of ezrin-associated protein network in human sperm capacitation.
The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.
EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation.
Arachidonic acid stimulates formation of a novel complex containing nucleolin and RhoA.
Local, persistent activation of Rho GTPases during plasticity of single dendritic spines.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics and cell adhesion.
Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity.
Toward an understanding of the protein interaction network of the human liver.
Effect of cancer-associated mutations in the PlexinB1 gene.
Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174Q.
WNT-3a modulates platelet function by regulating small GTPase activity.
A Salmonella typhimurium-translocated glycerophospholipid:cholesterol acyltransferase promotes virulence by binding to the RhoA protein switch regions.
Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.
Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.
Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration.
Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms.
A new mechanism of RhoA ubiquitination and degradation: roles of SCF(FBXL19) E3 ligase and Erk2.
The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1.
The RhoGAP ARHGAP19 controls cytokinesis and chromosome segregation in T lymphocytes.
Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis.
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.
An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration.
The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
A proteome-scale map of the human interactome network.
Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation.
Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils.
Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling.
Cadherin-11 coordinates cellular migration and extracellular matrix remodeling during aortic valve maturation.
Myo9b is a key player in SLIT/ROBO-mediated lung tumor suppression.
RHO binding to FAM65A regulates Golgi reorientation during cell migration.
Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion.
Architecture of the human interactome defines protein communities and disease networks.
Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding.
GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism.
Maximizing binary interactome mapping with a minimal number of assays.
Postzygotic inactivating mutations of RHOA cause a mosaic neuroectodermal syndrome.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Global mapping of Salmonella enterica-host protein-protein interactions during infection.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Multimodal cell maps as a foundation for structural and functional genomics.
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.
p115-RhoGEF activation of RHOA
NGF binding to p75NTR inactivates RHOA
p75NTR and RHOA-GDI interact
The p75NTR:NgR:MDGI complex reduces RHOA-GDI activity, displacing RHOA
RhoA is activated by nucleotide exchange and inhibits axonal growth
PIP3 binds to RhoA and activates it
Disassembly of tight junctions
SMURF1 binds phosphorylated PARD6A
SMURF1 ubiquitinates RHOA
DAAM1 recruits GTP-bound RHOA
RHOA:GTP binds ROCK, activating it
p190RhoGEF exchanges GTP for GDP on RHOA, activating it
RHOA:GTP:Mg2+ binds ROCK1,ROCK2
NGEF exchanges GTP for GDP on RHOA
Inactivation of Rho-GTP by p190RhoGAP
Activation of Rho by LARG and PDZ-RhoGEF
VAV2 is a GEF for Rho/Rac family kinases
VAV3 is a GEF for Rho/Rac family kinases
Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732
ROCK1,ROCK2 are activated
RHOA, RHOB, RHOC and RAC1 bind PKN1, PKN2 or PKN3
RHOA,RHOB,RHOC,RAC1:GTP:PKN1,2,3 binds PDPK1:PIP3
PDPK1 phosphorylates PKN1,2,3
Activated RHOA, RHOG, RAC1 and CDC42 bind KTN1 (kinectin)
RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1
RHOA:GTP:RTKN binds LIN7B
RHOA:GTP:RTKN binds TAX1BP3
RHOA:GTP binds RHPN1 or RHPN2
Activated CIT binds KIF14 and PRC1
OTUB1, (OTUB2) binds RNF128, TRAF3, TRAF6, RHOA
MEMO1 binds RHOA:GTP:DIAPH1
Exocytosis of secretory granule membrane proteins
Exocytosis of ficolin-rich granule membrane proteins
ARHGAP35 stimulates RHOA GTPase activity
RHOA GAPs stimulate RHOA GTPase activity
The p75NTR:NgR:MDGI binds RHOA-GDI
GDIs block activation of RHOA
RHOA binds effectors at the ER membrane
RHOA:GTP translocates to the ER membrane
RHOA binds effectors at the plasma membrane
TGFBR1 is recruited to tight junction by binding Pard6a
TGFBR2 is recruited to tight junctions-associated, Pard6a-bound, TGFBR1 after TGF-beta stimulation
TGFBR2 phosphorylates Pard6a
RhoA:GTP binds to activated Daam1
UniProtKB P61586 (RHOA_HUMAN) flat file