GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

DOI:10.1111/j.1574-6968.1987.tb02029.x

Purification and characterization of chromosomal streptomycin adenylyltransferase from derivatives of<i>Bacillus subtilis</i>Marburg 168

PMID:15984036

Molecular recognition of aminoglycoside antibiotics by bacterial defence proteins: NMR study of the structural and conformational features of streptomycin inactivation by Bacillus subtilis aminoglycoside-6-adenyl transferase.

PMID:17609790

Rescue of the streptomycin antibiotic activity by using streptidine as a "decoy acceptor" for the aminoglycoside-inactivating enzyme adenyl transferase.

PMID:3137862

Structure of adenylylated streptomycin synthesized enzymatically by Bacillus subtilis.

PMID:8293959

Genetic mapping in Bacillus subtilis 168 of the aadK gene which encodes aminoglycoside 6-adenylyltransferase.

file:genes/BACSU/aadK/aadK-uniprot.txt

UniProt flat file for aadK (P17585)

UniProt/CARD identity and protein naming for aadK.

"CC -!- FUNCTION: Mediates bacterial resistance to streptomycin CC (PubMed:17609790, PubMed:3137862). Adenylates streptomycin on the O-6 CC residue (PubMed:15984036, PubMed:17609790, PubMed:3137862). Adenylates"

file:projects/ANTIMICROBIAL_RESISTANCE/aro2go.sssom.yaml

Curated ARO to GO mapping set for AMR gene families

Manual ARO-to-GO mappings used to identify focused AMR annotation gains.

"mapping_set_title: ARO to GO mapping (AMR gene families and resistance mechanisms)"

file:projects/ANTIMICROBIAL_RESISTANCE/data/candidate_new_annotations.tsv

Annotation-gain candidates from ARO to GO mappings

Candidate GO annotations projected from the ARO-to-GO mapping set.

"Candidate GO annotations that UniProtKB entries with a CARD cross-reference would gain from the"