laeA (Aspergillus nidulans) — curation notes

UniProt C8VQG9 (LAEA_EMENI). Nuclear SAM-dependent methyltransferase; global
regulator of secondary metabolism; velvet-complex subunit. Velvet tier of the
conidiation_regulatory_cascade module.

• Global SM regulator: deletion blocks ST, penicillin, lovastatin clusters.
  PMID:15075281; PMID:15075281.
• Methyltransferase (IDA): automethylation to S-methylmethionine. PMID:23532849. Physiological substrate beyond automethylation still debated.
• Core MF GO:0008168 methyltransferase; core BP regulation of secondary metabolite
  biosynthesis. ascospore-formation, ST/penicillin metabolic-process, and
  fungivory/"interaction with host" annotations kept non-core (GO:0051701 is a
  loose fit — springtail is a predator, not a host).

2026-10-01 re-review (GOA refresh)

• No new or vanished GOA rows. Added supporting text to the nucleus IDA row (PMID:15075281).
  Other judgments unchanged.