Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
TIP120A associates with cullins and modulates ubiquitin ligase activity.
A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1.
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.
Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling.
The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc.
Acute myelogenous leukemia-derived SMAD4 mutations target the protein to ubiquitin-proteasome degradation.
Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein.
SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes.
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase.
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.
Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes.
Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.
Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.
Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.
Acetylation-dependent regulation of Skp2 function.
Domain-specific c-Myc ubiquitylation controls c-Myc transcriptional and apoptotic activity.
Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway.
DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage.
A High-Density Map for Navigating the Human Polycomb Complexome.
Architecture of the human interactome defines protein communities and disease networks.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.
Multimodal cell maps as a foundation for structural and functional genomics.
p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase.
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
Ubiquitination of p130 (RBL2) by SCF (Skp2)
Association of Cks1 with SCF(Skp2) complex
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
Degradation of ubiquitinated p27/p21 by the 26S proteasome
Ubiquitination of phospho-p27/p21
APC/C:Cdh1-mediated degradation of Skp2
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin
SCF(SKP2) complex binds RUNX2
SCF(SKP2) polyubiquitinates RUNX2
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex
CAND1 binds cytosolic CRL E3 ubiquitin ligases
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex
APC/C:Cdh1 polyubiquitinates SKP2
RB1 recruits APC/C:Cdh1 complex to SKP2
Defective RB1 does not form a complex with SKP2 and FZR1
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))
BACH1:FBXL17 binds SCF(SKP2) complex
Transfer of Ub from E2 to substrate and release of E2
Release of E3 from polyubiquitinated substrate
Polyubiquitination of substrate
Interaction of E3 with substrate and E2-Ub complex
Falcon deep research report for human SKP2