Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor.

Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components.

FAM111A protects replication forks from protein obstacles via its trypsin-like domain.

Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1.

FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease.

FAM111A induces nuclear dysfunction in disease and viral restriction.