Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB Subcellular Location vocabulary mapping
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation based on RHEA mapping of reactions
Combined Automated Annotation using Multiple IEA Methods
Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response.
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ERO1-Lbeta is a human EROs-family gene primarily localized to the ER, able to generate oxidative conditions in the ER (complementing the yeast ero1-1 mutant), with a distinct tissue distribution from ERO1-L and uniquely induced during the unfolded protein response.
Manipulation of oxidative protein folding and PDI redox state in mammalian cells.
Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p.
Disulphide production by Ero1α-PDI relay is rapid and effectively regulated.
The endoplasmic reticulum sulfhydryl oxidase Ero1β drives efficient oxidative protein folding with loose regulation.
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Recombinant human Ero1β is twice as active as Ero1α, oxidizes PDI more efficiently than other PDI family members, drives oxidative protein folding preferentially via the a domain of PDI, and is loosely regulated (Cys130 critical for feedback); it is constitutively expressed in professional secretory tissues and UPR-induced.
Reactome ER-lumen oxidative folding annotation for ERO1B
UniProt entry Q86YB8 (ERO1B_HUMAN), ERO1-like protein beta
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FAD-dependent ER sulfhydryl oxidase (EC 1.8.3.2) that reoxidizes P4HB/PDI (and other PDI-family members at lower rates) to drive disulfide-bond formation, passing electrons to O2 via FAD; peripheral lumenal-side ER membrane protein, homodimeric and heterodimeric with ERO1A; enriched in pancreatic islets and digestive tract; UPR-induced; implicated in proinsulin folding/glucose homeostasis.
Falcon deep research report for ERO1B