Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein.
Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein.
Production of amyloid beta protein precursor as a proteinase inhibitor by human astrocytic tumors.
Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain.
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein.
beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology.
Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2.
A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease.
Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function.
beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module.
Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity.
Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.
Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).
Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling.
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc.
The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.
The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.
A secreted form of human ADAM9 has an alpha-secretase activity for APP.
Signal transduction through tyrosine-phosphorylated carboxy-terminal fragments of APP via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.
Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein.
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.
Presenilin-1 interacts directly with the beta-site amyloid protein precursor cleaving enzyme (BACE1).
Generation of the beta-amyloid peptide and the amyloid precursor protein C-terminal fragment gamma are potentiated by FE65L1.
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.
MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time.
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice.
CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils.
In cerebrospinal fluid ER chaperones ERp57 and calreticulin bind beta-amyloid.
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.
A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease.
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Gerstmann-Sträussler-Scheinker disease amyloid protein polymerizes according to the "dock-and-lock" model.
Neurofibromatosis type 1 protein and amyloid precursor protein interact in normal human melanocytes and colocalize with melanosomes.
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease.
The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein.
Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function.
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.
ADAM19 is tightly associated with constitutive Alzheimer's disease APP alpha-secretase in A172 cells.
Aluminum inhibits proteolytic degradation of amyloid beta peptide by cathepsin D: a potential link between aluminum accumulation and neuritic plaque deposition.
Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease.
Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease.
Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice.
Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine.
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway.
Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter.
Cystatin C modulates cerebral beta-amyloidosis.
Evidence of fibril-like β-sheet structures in a neurotoxic amyloid intermediate of Alzheimer's β-amyloid.
Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling.
A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein.
Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells.
Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy.
Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Abeta40.
Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains.
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.
In vitro perturbation of aggregation processes in beta-amyloid peptides: a spectroscopic study.
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.
Synaptic transmission block by presynaptic injection of oligomeric amyloid beta.
Alpha-helix targeting reduces amyloid-beta peptide toxicity.
Quenched hydrogen/deuterium exchange NMR characterization of amyloid-beta peptide aggregates formed in the presence of Cu2+ or Zn2+.
Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease.
Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.
Structure-neurotoxicity relationships of amyloid beta-protein oligomers.
Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy.
Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.
The thioflavin T fluorescence assay for amyloid fibril detection can be biased by the presence of exogenous compounds.
Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity.
CD74 interacts with APP and suppresses the production of Abeta.
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction.
Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption.
Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity.
Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.
The novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor protein.
Memory impairment in transgenic Alzheimer mice requires cellular prion protein.
Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins.
Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.
Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
An aminopeptidase from Streptomyces sp. KK565 degrades beta amyloid monomers, oligomers and fibrils.
Activation of nicotinic α(7) acetylcholine receptor enhances long term potentation in wild type mice but not in APP(swe)/PS1ΔE9 mice.
Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.
Perlecan domain V inhibits α2 integrin-mediated amyloid-β neurotoxicity.
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.
Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease.
Lysophosphatidylcholine modulates fibril formation of amyloid beta peptide.
Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake.
Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling.
Lipid matrix plays a role in Abeta fibril kinetics and morphology.
Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease.
WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity.
Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease.
Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation.
Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift.
The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.
TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation.
Effect of N-homocysteinylation on physicochemical and cytotoxic properties of amyloid β-peptide.
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease.
Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways.
Search for amyloid-binding proteins by affinity chromatography.
Dimeric structure of transmembrane domain of amyloid precursor protein in micellar environment.
Open-closed motion of Mint2 regulates APP metabolism.
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.
Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.
Antimicrobial activity of human islet amyloid polypeptides: an insight into amyloid peptides' connection with antimicrobial peptides.
A comparative analysis of the aggregation behavior of amyloid-β peptide variants.
Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones.
LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway.
Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms.
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
Interaction between soluble Aβ-(1-40) monomer and Aβ-(1-42) fibrils probed by paramagnetic relaxation enhancement.
Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality.
N-terminal domain of Pyrococcus furiosus l-asparaginase functions as a non-specific, stable, molecular chaperone.
Generation of amyloid-β is reduced by the interaction of calreticulin with amyloid precursor protein, presenilin and nicastrin.
NMR characterization of the interaction of GroEL with amyloid β as a model ligand.
Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease.
Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro.
FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease.
Two β-strands of RAGE participate in the recognition and transport of amyloid-β peptide across the blood brain barrier.
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein.
Impact of the cellular prion protein on amyloid-β and 3PO-tau processing.
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.
Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin.
Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.
Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model.
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.
FKBP12 regulates the localization and processing of amyloid precursor protein in human cell lines.
The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway.
sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin.
Molecular basis of substrate recognition and degradation by human presequence protease.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Modeling an in-register, parallel "iowa" aβ fibril structure using solid-state NMR data from labeled samples with rosetta.
A genome-wide gene-expression analysis and database in transgenic mice during development of amyloid or tau pathology.
Structural basis for amyloidogenic peptide recognition by sorLA.
Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9.
Quantitative interaction proteomics of neurodegenerative disease proteins.
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.
The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1.
High-resolution NMR characterization of low abundance oligomers of amyloid-β without purification.
Dual pathways mediate β-amyloid stimulated glutathione release from astrocytes.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?
ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance.
The Protective Role of microRNA-200c in Alzheimer's Disease Pathologies Is Induced by Beta Amyloid-Triggered Endoplasmic Reticulum Stress.
Apolipoprotein E-mediated Modulation of ADAM10 in Alzheimer's Disease.
Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
Fibril structure of amyloid-β(1-42) by cryo-electron microscopy.
Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice.
Reduced expression of Na(+)/Ca(2+) exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice.
Hypoxia increases amyloid-β level in exosomes by enhancing the interaction between CD147 and Hook1.
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Probing the Mint2 Protein-Protein Interaction Network Relevant to the Pathophysiology of Alzheimer's Disease.
miR-15b reduces amyloid-β accumulation in SH-SY5Y cell line through targetting NF-κB signaling and BACE1.
TMEM30A is a candidate interacting partner for the β-carboxyl-terminal fragment of amyloid-β precursor protein in endosomes.
TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease.
Visualization of Alzheimer's Disease Related α-/β-/γ-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer.
HENA, heterogeneous network-based data set for Alzheimer's disease.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Implications of Oligomeric Amyloid-Beta (oAβ(42)) Signaling through α7β2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
First identification of ITM2B interactome in the human retina.
Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
A physical wiring diagram for the human immune system.
Multimodal cell maps as a foundation for structural and functional genomics.
Serine proteinase inhibitors in human skeletal muscle: expression of beta-amyloid protein precursor and alpha 1-antichymotrypsin in vivo and during myogenesis in vitro.
APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein.
Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.
The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
Association of human, rat, and rabbit apolipoprotein E with beta-amyloid.
Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease.
Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide.
An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease.
Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein.
Solution structure of methionine-oxidized amyloid beta-peptide (1-40). Does oxidation affect conformational switching?
Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor.
NLRP3 oligomerizes via NACHT domains
AGRN binds Beta amyloid fibril via GAG chains
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
Liganded Gi-activating GPCR acts as a GEF for Gi
Exocytosis of platelet alpha granule contents
AP4 transports APP from trans-Golgi network to endosome lumen
BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)
APP(672-713),APP(672-711) translocate from endosome lumen to extracellular region
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
The Ligand:GPCR:Gq complex dissociates
The Ligand:GPCR:Gi complex dissociates
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
NLRP3 activation by elicitor proteins
NLRP3 recruits PYCARD (ASC) via a PYD-PYD interaction
PYCARD recruits procaspase-1 via CARD
Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor
SORL1 transports APP(18-770) from endosome lumen to Golgi lumen
FAM20C phosphorylates FAM20C substrates
ADAM10:Zn2+:TSPANs cleaves APP(18-770)
APP translocates from plasma membrane to endosome lumen
Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)
SGTA binds mislocalized membrane protein
Amyloid fibrils have additional components
Amyloid precursor proteins form ordered fibrils
HTRA2 degrades APP (Amyloid-beta precursor protein)
UniProt text export for APP (P05067)
Falcon deep research report for APP