Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4.
Functional characterization of human monocarboxylate transporter 6 (SLC16A5).
Towards a proteome-scale map of the human protein-protein interaction network.
Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice.
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization.
Fibrillins, fibulins, and matrix-associated glycoprotein modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Latent transforming growth factor beta-binding proteins and fibulins compete for fibrillin-1 and exhibit exquisite specificities in binding sites.
Differential regulation of elastic fiber formation by fibulin-4 and -5.
Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase.
Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression.
Yeast two-hybrid analysis of a human trabecular meshwork cDNA library identified EFEMP2 as a novel PITX2 interacting protein.
Protein interactions of the transcription factor Hoxa1.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice.
Fibulin-3, -4, and -5 are highly susceptible to proteolysis, interact with cells and heparin, and form multimers.
Elastic fibres in health and disease.
Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
A proteome-scale map of the human interactome network.
Fibulin-4 is associated with tumor progression and a poor prognosis in ovarian carcinomas.
Widespread macromolecular interaction perturbations in human genetic disorders.
Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities.
Loss of fibulin-4 disrupts collagen synthesis and maturation: implications for pathology resulting from EFEMP2 mutations.
Forelimb contractures and abnormal tendon collagen fibrillogenesis in fibulin-4 null mice.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells.
MatrisomeDB 2.0: 2023 updates to the ECM-protein knowledge database.
PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics.
Fibulin binds elastic fibres
Elastic fibres bind associated proteins
Cysteine-rich tail protein 1
Monocarboxylate transporter 6
T-cell leukemia homeobox protein 3
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
Homeobox protein prophet of Pit-1
Serine/threonine-protein kinase 16
Retinol-binding protein 3
Insulin-like growth factor-binding protein 6
Hippocalcin-like protein 1
Prostaglandin E2 receptor EP3 subtype
Large proline-rich protein BAG6
Max-interacting protein 1
Large ribosomal subunit protein bL12m
Transcription factor LBX1
Keratin-associated protein 12-2
Keratin-associated protein 10-8
Cyclic AMP-responsive element-binding protein 5
Ras-related protein Rab-40B
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Keratin-associated protein 19-5
Keratin-associated protein 13-3
Late cornified envelope protein 3C
Late cornified envelope protein 3E
Late cornified envelope protein 1C
Late cornified envelope protein 1E
Late cornified envelope protein 1A
Late cornified envelope protein 3A
Late cornified envelope protein 2C
Late cornified envelope protein 2D
Cysteine-rich DPF motif domain-containing protein 1
Keratin-associated protein 26-1
Spermatogenesis-associated protein 8
Solute carrier family 25 member 48
FMR1-interacting protein NUFIP2
Spermatogenesis-associated protein 24
Keratin-associated protein 11-1
Tripartite motif-containing protein 42
E3 ubiquitin-protein ligase LNX
E3 ubiquitin-protein ligase RNF138
U4/U6 small nuclear ribonucleoprotein Prp31
RNA-binding protein with multiple splicing
F-box/WD repeat-containing protein 5
Arrestin domain-containing protein 3
Sperm acrosome-associated protein 9
Small glutamine-rich tetratricopeptide repeat-containing protein beta
Heat shock 70 kDa protein 12B
Rhox homeobox family member 2
THAP domain-containing protein 7
AP-1 complex subunit mu-1
Late cornified envelope protein 3D
Keratin-associated protein 3-2
Protein sprouty homolog 4
Alpha-ketoglutarate-dependent dioxygenase FTO
3 beta-hydroxysteroid dehydrogenase type 7
Anaphase-promoting complex subunit 11
RB-associated KRAB zinc finger protein
Solute carrier family 23 member 1
Ubiquitin carboxyl-terminal hydrolase 21
EGF-containing fibulin-like extracellular matrix protein 2