Gene Ontology annotation through association of InterPro records with GO terms
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A sequence-specific DNA-binding protein that activates fushi tarazu segmentation gene expression.
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DNA-binding-site mutagenesis and reporter expression support transcriptional activation.
"The results suggest that FTZ-F1 is a transcriptional activator necessary for the proper expression of the ftz gene."
Crystal structure of Fushi tarazu factor 1 ligand binding domain/Fushi tarazu peptide complex identifies new class of nuclear receptors.
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The crystallized regulatory domain has an intramolecular helix occupying the canonical ligand pocket.
"the ligand-binding pocket of the FTZ-F1 LBD is completely occupied by helix 6 (H6) of the receptor"
Solution Nuclear Magnetic Resonance Studies of the Ligand-Binding Domain of an Orphan Nuclear Receptor Reveal a Dynamic Helix in the Ligand-Binding Pocket.
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Solution dynamics and binding assays reveal phospholipid binding despite the closed crystal conformation.
"Indeed, we show that the Ftz-F1 LBD can bind phospholipids, not unlike its orthologs."
A molecular mechanism for the stage specificity of the Drosophila prepupal genetic response to ecdysone.
Temporally restricted expression of transcription factor betaFTZ-F1: significance for embryogenesis, molting and metamorphosis in Drosophila melanogaster.
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BetaFTZ-F1 localizes to nuclei before ecdysis and pupation.
"betaFTZ-F1, is expressed in the nuclei of almost all tissues slightly before the first and second larval ecdysis and before pupation."
Functional conservation of Drosophila FTZ-F1 and its mammalian homologs suggests ligand-independent regulation of NR5A family transcriptional activity.
Potential role for a FTZ-F1 steroid receptor superfamily member in the control of Drosophila metamorphosis.
UniProtKB M9NFK2 sequence and domain features
FTZ-F1 isoform sequence comparison and prediction-attribution records