Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Falcon deep research synthesis for HSPB6
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HSPB6 is an ATP-independent small heat shock protein holdase with phosphorylation-regulated 14-3-3/cofilin signaling roles in smooth muscle relaxation and cardioprotection.
"HSPB6 belongs to the small heat shock protein family. Functionally, sHSPs are ATP-independent "holdase" chaperones that can modulate proteostasis by binding aggregation-prone proteins."
Some properties of human small heat shock protein Hsp20 (HspB6).
HSPB7 is a SC35 speckle resident small heat shock protein.
Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction.
Hsp20 functions as a novel cardiokine in promoting angiogenesis via activation of VEGFR2.
Structure and properties of G84R and L99M mutants of human small heat shock protein HspB1 correlating with motor neuropathy.
Molecular structure and dynamics of the dimeric human small heat shock protein HSPB6.
Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.
The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation
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PKA phosphorylates HSPB6 at Ser16; phospho-HSPB6 binds 14-3-3gamma whereas non-phosphorylated HSPB6 does not
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Phospho-HSPB6 can displace phospho-cofilin from 14-3-3, allowing cofilin activation and actin depolymerization
Large potentials of small heat shock proteins
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HSPB6 mediates cyclic nucleotide-dependent force suppression in smooth muscle through phosphorylation-dependent actin remodeling via the 14-3-3/cofilin axis
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HSPB6 associates with actin and alpha-actinin at low stoichiometry (monomer ratio less than 0.04); Ser16 phosphorylation causes dissociation
Transduction of phosphorylated heat shock-related protein 20, HSP20, prevents vasospasm of human umbilical artery smooth muscle
Regulation of BECN1-mediated autophagy by HSPB6: Insights from a human HSPB6 <sup>S10F</sup> mutant
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The DCM-associated S10F variant promotes BECN1 ubiquitination and proteasomal degradation, inhibiting autophagic flux and increasing apoptosis
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HSPB6 S10F transgenic mice develop progressive cardiomyopathy with ejection fraction reduced to approximately 50 percent by 16 months and premature death
HSPB6 - a lipid-dependent molecular chaperone inhibits alpha-synuclein aggregation
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HSPB6 binds membrane lipids with Kd values of 0.045-0.095 micromolar across different organelle lipid compositions
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HSPB6 abrogates lipid-induced alpha-synuclein aggregation at 1:100 HSPB6:alpha-syn ratio, acting at membrane-associated aggregation steps
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Aggregation half-time correlates with HSPB6 lipid affinity (Pearson r equals 0.85, p equals 0.0375)