Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: potential regulation of the glucocorticoid receptor.
Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor.
Loss of IL-6 receptor expression in cervical carcinoma cells inhibits autocrine IL-6 stimulation: abrogation of constitutive monocyte chemoattractant protein-1 production.
Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6.
Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.
Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts.
Gp130 activation by soluble interleukin-6 receptor/interleukin-6 enhances osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells.
JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression.
Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2.
Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF.
Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.
Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex.
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).
Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling.
Cytokines promote Wnt signaling and inflammation and impair the normal differentiation and lipid accumulation in 3T3-L1 preadipocytes.
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma.
BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription.
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation.
Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells.
Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma.
Interleukin-6 regulates pancreatic alpha-cell mass expansion.
Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex.
Marked cell-type-specific differences in glycosylation of human interleukin-6.
IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins.
Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway.
Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats.
Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor.
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.
Molecular cloning and expression of an IL-6 signal transducer, gp130.
SASH1 is a scaffold molecule in endothelial TLR4 signaling.
Inhibition of IL-6 family cytokines by SOCS3.
Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.
miR26a modulates Th17/T reg balance in the EAE model of multiple sclerosis by targeting IL6.
Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis.
Down-regulation of microRNA-9 leads to activation of IL-6/Jak/STAT3 pathway through directly targeting IL-6 in HeLa cell.
Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment.
Dysregulated miR-98 Contributes to Extracellular Matrix Degradation by Targeting IL-6/STAT3 Signaling Pathway in Human Intervertebral Disc Degeneration.
Role of TNF in mast cell neuroinflammation and pain.
Plasma miR-26a as a Diagnostic Biomarker Regulates Cytokine Expression in Systemic Juvenile Idiopathic Arthritis.
Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes.
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic T(H)17 cells.
SorLA in Interleukin-6 Signaling and Turnover.
Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6).
miR-146a suppresses STAT3/VEGF pathways and reduces apoptosis through IL-6 signaling in primary human retinal microvascular endothelial cells in high glucose conditions.
A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity.
IL-6 signalling pathways and the development of type 2 diabetes.
TNF-α-sensitive brain pericytes activate microglia by releasing IL-6 through cooperation between IκB-NFκB and JAK-STAT3 pathways.
Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines.
Soluble gp130 prevents interleukin-6 and interleukin-11 cluster signaling but not intracellular autocrine responses.
Regulation of IL-6 signaling by miR-125a and let-7e in endothelial cells controls vasculogenic mimicry formation of breast cancer cells.
Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling.
Physical proximity and functional cooperation of glycoprotein 130 and glycoprotein VI in platelet membrane lipid rafts.
Synergistic activation of human T cells by interleukin 1 and interleukin 6.
Reciprocal regulation of miR-206 and IL-6/STAT3 pathway mediates IL6-induced gefitinib resistance in EGFR-mutant lung cancer cells.
miR-98 Modulates Cytokine Production from Human PBMCs in Systemic Lupus Erythematosus by Targeting IL-6 mRNA.
Regulation of adipose tissue inflammation by interleukin 6.
Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6.
A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.
Increased IL-6 and Potential IL-6 trans-signalling in the airways after an allergen challenge.
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin.
IL-6/JAK/STAT3 Signaling in Breast Cancer Metastasis: Biology and Treatment.
Structural insights into the assembly of gp130 family cytokine signaling complexes.
Targeting IL-6 trans-signalling: past, present and future prospects.
Mitogen-activated protein kinases and ribosomal S6 protein kinases are involved in signaling pathways shared by interleukin-11, interleukin-6, leukemia inhibitory factor, and oncostatin M in mouse 3T3-L1 cells.
Interleukin-6 suppression of neutrophil apoptosis is neutrophil concentration dependent.
Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells.
Platelet activation induced by interleukin-6: evidence for a mechanism involving arachidonic acid metabolism.
Interleukin 6 induces the expression of vascular endothelial growth factor.
Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex.
Both Stat3-activation and Stat3-independent BCL2 downregulation are important for interleukin-6-induced apoptosis of 1A9-M cells.
IL6:IL6R-2 binds IL6ST:JAK1, JAK2, (TYK2)
Assembly of hexameric IL-6 receptor
IL6:IL6R binds IL6ST:JAK1,JAK2,(TYK2)
IL6ST is tyrosine phosphorylated
Tyrosine phosphorylated IL6ST binds STAT1,STAT3
Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor
Phosphorylated STATs are released
PTPN11 binds p-Y759-IL6ST
Serine phosphorylation of STATs
Regulation of IL6 transcription
IL10 negatively regulates extracellular inflammatory mediators
Expression of IL4,IL13-downregulated extracellular genes
Expression of STAT3-upregulated extracellular proteins
FAM20C phosphorylates FAM20C substrates
IL6 gene produces IL6 protein
Tyrosine phosphorylation of STAT3 by IL6 receptor
NFκB stimulates IL6 gene expression
p-Y705-STAT3 dissociates from IL6 receptor
Tyrosine phosphorylated IL6ST binds STAT3
UniProtKB record for human IL6