Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
TreeGrafter-generated GO annotations
UniProtKB record A0A0H2MHV8 (A0A0H2MHV8_VARPD) - Alpha-ketoglutarate-dependent taurine dioxygenase (tauD1 / VPARA_23370) from Variovorax paradoxus TBEA6
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VPARA_23370 (tauD1) encodes a 302-aa alpha-ketoglutarate-dependent taurine dioxygenase containing the full-length TauD/TfdA-like dioxygenase domain (Pfam PF02668, residues 23-294; InterPro IPR003819; PANTHER PTHR30468:SF1).
"FT DOMAIN 23..294
FT /note="TauD/TfdA-like"
FT /evidence="ECO:0000259|Pfam:PF02668""
Characterization of alpha-ketoglutarate-dependent taurine dioxygenase from Escherichia coli.
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Bacterial TauD is a soluble homodimeric Fe(II)- and alpha-ketoglutarate-dependent dioxygenase that cleaves taurine (Km = 55 uM) as well as short-chain aliphatic sulfonates into sulfite and the corresponding aldehyde under sulfate starvation.
"The pure enzyme converted taurine to sulfite and aminoacetaldehyde, which was identified by high pressure liquid chromatography after enzymatic conversion to ethanolamine. The reaction also consumed equimolar amounts of oxygen and alpha-ketoglutarate; ferrous iron was absolutely required for activity; and ascorbate stimulated the reaction."