UniProtKB P07602 (SAP_HUMAN) prosaposin entry
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Binding and transport of gangliosides by prosaposin.
Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles.
Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Crystal structures of human saposins C andD: implications for lipid recognition and membrane interactions.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomics characterization of extracellular space components in the human aorta.
Regulation of cell proliferation and apoptosis through fibrocystin-prosaposin interaction.
Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.
The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting.
Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling.
Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.
Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin.
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.
Prosaposin is a regulator of progranulin levels and oligomerization.
Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.
Lysosomal processing of progranulin.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
GBA1:SAPC hydrolyzes GlcCer
Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2
bHEXA,bHEXB hydrolyze PSAP(195-273):Gb4Cer:PE
NEU1,4 hydrolyze PSAP(195-273):GM3:PE
GLA hydrolyzes PSAP(195-273):Gb3Cer:PE
GLB1 hydrolyzes SapB/C:LacCer
ARSA removes sulfate from PSAP(195-273):Sulfatide
Exocytosis of Proactivator polypeptide
Liganded Gi-activating GPCR acts as a GEF for Gi
Exocytosis of azurophil granule membrane proteins
The Ligand:GPCR:Gi complex dissociates
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
PSAP(195-273) dimer:PE binds and mobilizes ligands
PSAP(195-273) forms a dimer
GLA hydrolyzes PSAP(195-273):Gal2Cer:PE
PSAP(195-273) dimer binds PE