GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:23160002

Peptidomic discovery of short open reading frame-encoded peptides in human cells.

ASNSD1-SEP detected by peptidomics in K562 cells, quantified by isotope dilution, and localized to the cytoplasm as a FLAG-tagged construct in HEK293T cells.

"examined the cellular concentrations (K562 cells) of three selected SEPs (ASNSD1-SEP, PHF19-SEP and H2AFx-SEP) using isotope dilution mass spectrometry"

PMID:31738558

Upstream ORF-Encoded ASDURF Is a Novel Prefoldin-like Subunit of the PAQosome.

ASDURF is the 12th PAQosome subunit and a beta-prefoldin-like member of the heterohexameric prefoldin-like module.

"ASDURF displays significant structural homology to β-prefoldins"

PMID:38176414

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma.

ASDURF (ASNSD1-uORF) is a dependency of MYC-driven medulloblastoma cells, interacts directly with the prefoldin-like complex, and co-varies with prefoldin-like subunits in DepMap/PRISM knockout profiles.

"A microprotein encoded by one of these ORFs, ASNSD1-uORF or ASDURF, was upregulated, associated with MYC-family oncogenes, and promoted medulloblastoma cell survival through engagement with the prefoldin-like chaperone complex."

PMID:38242097

Actions speak louder than ORFs: A non-canonical microprotein promotes medulloblastoma oncogenesis.