Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
A proteome-scale map of the human interactome network.
A reference map of the human binary protein interactome.
UniProt entry Q8N6R1 (SERP2_HUMAN), stress-associated endoplasmic reticulum protein 2 / RAMP4-2
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Single-pass ER membrane protein of the RAMP4 family (SERP1 paralog) that interacts with target proteins during ER translocation, protects unfolded targets against degradation during ER stress, and facilitates their glycosylation after stress; interacts with the SEC61 complex and calnexin.
The intramembrane protease SPPL2c promotes male germ cell development by cleaving phospholamban.
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RAMP4-2 (= SERP2; UniProt AltName "Ribosome-associated membrane protein RAMP4-2") is a tail-anchored ER membrane protein experimentally shown to be a substrate for intramembrane proteolysis; among the tail-anchored candidates tested it was efficiently cleaved by SPPL2c (and also by SPP), implicating SERP2 in regulated ER-membrane proteostasis/turnover.
The transmembrane domain of Frey1 harbors a transplantable inhibitory motif for intramembrane proteases.
RAMPing up knowledge of the translocon.
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eLife Insight on cryo-EM of ribosome-translocon complexes; RAMP4-family proteins localize at the Sec61 lateral gate and are proposed to act as a dynamic, gating-modulating component of the translocon, providing family-level context for the RAMP4-family member SERP2.
A clearer picture of the ER translocon complex.