Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens.
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RAD18 is essential for postreplication repair
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RAD18 dysfunction causes sensitivity to UV, MMS, and mitomycin C
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RAD18 binds to RAD6 through conserved ring-finger motif
The human RAD18 gene product interacts with HHR6A and HHR6B.
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Human RAD18 forms stable complexes with UBE2A (HHR6A) and UBE2B (HHR6B)
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RAD18 is ubiquitously expressed in human tissues
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RAD18 plays role in lesion bypass mechanisms
BRCTx is a novel, highly conserved RAD18-interacting protein.
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BRCTx binds to C-terminus of RAD18
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RAD18 and BRCTx colocalize in nucleus
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BRCTx localizes to nucleus and centrosome
Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.
Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks.
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RAD18-RAD6B preferentially binds forked and ssDNA structures
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SAP domain (residues 248-282) is crucial for DNA binding
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SAP domain is required for efficient PCNA monoubiquitination
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RAD18 recruits Pol eta to stalled replication forks
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks.
RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage.
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RAD18 interacts with BRCTx in phosphorylation-dependent manner
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RAD18-BRCTx module is critical for UV damage repair
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RAD18 forms nuclear inclusion bodies
Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response.
Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks.
DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis.
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RAD18 exists in monoubiquitinated and non-ubiquitinated forms
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RAD18 is deubiquitinated after MMS or H2O2 treatment
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Ubiquitinated RAD18 preferentially binds non-ubiquitinated RAD18
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RAD18 deubiquitination promotes SHPRH interaction for error-free bypass
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RAD18 forms nuclear foci after DNA damage
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RAD18 autoubiquitination is promoted by RAD6
DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links.
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RAD18 forms complex with SLF1 and SLF2
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RAD18-SLF1-SLF2 recruits SMC5/6 to DNA lesions
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RAD18 suppresses genome instability at ICLs
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
A proteome-scale map of the human interactome network.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Architecture of the human interactome defines protein communities and disease networks.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
LncRNA CTBP1-DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanisms.
A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling.
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA
RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA
SHPRH polyubiquitinates monoubiquitinated PCNA
SHPRH binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N
HLTF polyubiquitinates monoubiquitinated PCNA
HLTF binds monoUb-K164-PCNA, RAD6:RAD18, UBE2V2:Ub:UBE2N
Deep research report on RAD18
Cyberian deep research on RAD18 function