Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
Regulation of glycogen phosphorylase. Role of the peptide region surrounding the phosphoserine residue in determining enzyme properties.
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Skeletal muscle glycogen phosphorylase is regulated through phosphorylation of its N-terminal region (phosphorylase b to a), AMP allosteric activation, glucose-6-P inhibition, and dimer-to-tetramer association.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.
A proteome-scale map of the human interactome network.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A proteome-scale map of the SARS-CoV-2-human contactome.
Molecular genetic heterogeneity of myophosphorylase deficiency (McArdle's disease).
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Loss-of-function mutations in the muscle glycogen phosphorylase gene cause McArdle disease, a common cause of exercise intolerance, muscle cramps, and recurrent myoglobinuria.
Molecular diagnosis of McArdle disease: revised genomic structure of the myophosphorylase gene and identification of a novel mutation.
PYGM b dimer:AMP complex => PYGM dimer, b form + 2 AMP
PYGM dimer, b form + 2 AMP => PYGM b dimer:AMP complex
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP