enok (Q9W1A9) review notes

Identity and activity

• KAT6/MOZ-MORF family MYST HAT; identified from mushroom body neuroblast proliferation defects. PMID:11231125
• Major H3K23 acetyltransferase; all Enok complex subunits needed. PMID:27198229 PMID:27198229

Complex and cell cycle

• Enok, Br140, Eaf6, Ing5 copurify. PMID:27198229
• G1/S via Elg1/PCNA. PMID:27198229

Transcription / piRNA

• PMID:33524038

Development

• GSC maintenance PMID:24120347

Curation decisions (shared across Enok complex genes Br140, Ing5, Eaf6)

• MOZ/MORF complex ACCEPT for all subunits.
• "DNA strand elongation involved in DNA replication" IDA (all four subunits) MODIFY -> GO:0000082 G1/S transition of mitotic cell cycle: the paper measures a G1/S block and chromatin-bound PCNA, not strand elongation.
• Acetyltransferase activator activity ACCEPT for the three non-catalytic subunits.
• enok: generic HAT / H3 HAT / catalytic activity MODIFY -> GO:0043994 H3K23 acetyltransferase; H15-domain-derived nucleosome and nucleosome assembly IEA REMOVE.

Deep research (falcon, added after initial review)

• enok-deep-research-falcon.md agrees: H3K23 is the best-established site ["H3K23 is the most securely established physiological site"]; Enok is a major but not exclusive H3K23 writer (CBP/nejire contributes at ecdysone genes); Br140 stimulates Enok activity. It explicitly warns the H1/H5 (H15) domain mapping should not make Enok a linker histone, supporting removal of the nucleosome / nucleosome assembly IEAs. No annotation decisions changed.