Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000122

AtSubP analysis

PMID:10823923

The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative Na+/H+ antiporter.

"SOS1 is cloned and predicted to encode a 127-kDa protein with 12 transmembrane domains in the N-terminal part and a long hydrophilic cytoplasmic tail in the C-terminal part."
"SOS1 is expected to function in exporting Na + from the cytosol to the extracellular space to prevent rapid accumulation of Na + in the cytoplasm."

PMID:11874577

Salt causes ion disequilibrium-induced programmed cell death in yeast and plants.

"salt-sensitive mutants of yeast (cnb1Delta) and Arabidopsis (sos1) exhibit substantially more profound PCD symptoms, indicating that salt-induced PCD is mediated by ion disequilibrium"

PMID:11884687

The putative plasma membrane Na(+)/H(+) antiporter SOS1 controls long-distance Na(+) transport in plants.

"These results suggest that SOS1 is critical for controlling long-distance Na + transport from root to shoot."
"SOS1 activity was specific for Na + because the plant protein was inefficient for K + efflux or uptake in vivo"

PMID:12239394

SOS1, a Genetic Locus Essential for Salt Tolerance and Potassium Acquisition.

"The sos1 mutants are specifically hypersensitive to Na+ and Li+."
"Uptake experiments using 86Rb showed that sos1 mutants are defective in high-affinity potassium uptake."

PMID:12938931

Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis.

"This proteomic study enabled us to identify 392 nonredundant proteins."

PMID:14506206

Large-scale analysis of in vivo phosphorylated membrane proteins by immobilized metal ion affinity chromatography and mass spectrometry.

"identification of plasma membrane phosphoproteins of Arabidopsis"

PMID:17023541

The plasma membrane Na+/H+ antiporter SOS1 interacts with RCD1 and functions in oxidative stress tolerance in Arabidopsis.

"SOS1 interacts through its predicted cytoplasmic tail with RCD1, a regulator of oxidative-stress responses."

PMID:17996020

Reactive oxygen species mediate Na+-induced SOS1 mRNA stability in Arabidopsis.

"Salt Overly Sensitive 1 (SOS1), a plasma membrane Na+/H+ antiporter in Arabidopsis, is a salt tolerance determinant crucial for the maintenance of ion homeostasis in saline stress conditions."

PMID:21262798

Activation of the plasma membrane Na/H antiporter Salt-Overly-Sensitive 1 (SOS1) by phosphorylation of an auto-inhibitory C-terminal domain.

"SOS1 is maintained in a resting state by a C-terminal auto-inhibitory domain that is the target of SOS2-SOS3."

file:ARATH/SOS1/SOS1-uniprot.txt

UniProt entry NHX7_ARATH (Q9LKW9)

"Required for cytoplasmic Na(+) and Li(+) detoxification by secreting them from the cytoplasm to the extracellular space. Regulates Na(+) content of the xylem sap."
"Acts in electroneutral exchange of protons for cations such as Na(+) or Li(+) across plasma membrane."

file:ARATH/SOS1/SOS1-deep-research-falcon.md

Falcon (Edison Scientific) deep research report for SOS1

"SOS1/NHX7 mediates active Na+ efflux from the cytosol in exchange for H+, lowering cytosolic Na+ during salt stress."