UniProtKB entry P35557 (HXK4_HUMAN), glucokinase / hexokinase-4
Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase.
Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner.
The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.
Insights into the biochemical and genetic basis of glucokinase activation from naturally occurring hypoglycemia mutations.
Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.
Effects of novel maturity-onset diabetes of the young (MODY)-associated mutations on glucokinase activity and protein stability.
Biochemical basis of glucokinase activation and the regulation by glucokinase regulatory protein in naturally occurring mutations.
Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity-onset diabetes of the young (MODY2) patients.
Activating mutations in the human glucokinase gene revealed by genetic selection.
Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion.
Insights into the pathogenicity of rare missense GCK variants from the identification and functional characterization of compound heterozygous and double mutations inherited in cis.
Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner.
Phenotypic severity of homozygous GCK mutations causing neonatal or childhood-onset diabetes is primarily mediated through effects on protein stability.
A reference map of the human binary protein interactome.
Sugar specificity of human beta-cell glucokinase: correlation of molecular models with kinetic measurements.
Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations.
Structure/function studies of human beta-cell glucokinase. Enzymatic properties of a sequence polymorphism, mutations associated with diabetes, and other site-directed mutants.
Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships.
Impaired hepatic glycogen synthesis in glucokinase-deficient (MODY-2) subjects.
Organization of the human glucokinase regulator gene GCKR.
NPC transports GCK1:GCKR from cytosol to nucleoplasm
cytosolic GCK1:GKRP complex <=> glucokinase (GCK1) + glucokinase regulatory protein (GKRP)
nucleoplasmic GCK1:GCKR complex => glucokinase (GCK1) + glucokinase regulatory protein (GCKR)
glucokinase (GCK1) + glucokinase regulatory protein (GKRP) <=> GCK1:GKRP complex
NPC exports GCK1 from nucleus
Defective GCK does not phosphorylate Glc to form G6P
Defective NPC does not transport GCK1:GKRP from cytosol to nucleoplasm
HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P