Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Identification of a new Pyk2 target protein with Arf-GAP activity.
Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis.
Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain.
Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor.
The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1.
Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor.
FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P.
Specificity, promiscuity and localization of ARF protein interactions with NCS-1 and phosphatidylinositol-4 kinase-III beta.
Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes.
Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.
Dissecting the role of the ARF guanine nucleotide exchange factor GBF1 in Golgi biogenesis and protein trafficking.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
The ADP-ribosylation factor 1 (Arf1) is involved in regulating copper uptake.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kγ activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
The BAR domain protein Arfaptin-1 controls secretory granule biogenesis at the trans-Golgi network.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Hepatitis C virus triggers Golgi fragmentation and autophagy through the immunity-related GTPase M.
Maximizing binary interactome mapping with a minimal number of assays.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Targeting ARF1-IQGAP1 interaction to suppress colorectal cancer metastasis and vemurafenib resistance.
Loss of ARF5 impairs recovery after lysosomal damage.
Hydrolysis of bound GTP by ARF protein triggers uncoating of Golgi-derived COP-coated vesicles.
Evidence for ADP-ribosylation-factor-mediated activation of phospholipase D by m3 muscarinic acetylcholine receptor.
ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling.
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ARF1 is a negative regulator of cGAS-STING type I interferon signaling; GTPase-defective heterozygous ARF1 missense mutations (e.g. R99C/R99H) cause a type I interferonopathy, with mutant ARF1 perturbing mitochondrial integrity (driving mtDNA release and cGAS activation) and causing accumulation of active STING at the Golgi/ERGIC due to defective retrograde transport.
Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis.
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Arf1 integrates cellular metabolism with energy production by regulating fatty-acid storage and utilization; a hyperactive Arf1 mutant causes fatty-acid accumulation in lipid droplets, mitochondrial fragmentation, and decreased ATP synthesis, with the role in fatty-acid metabolism conserved in mammals and proposed to act via organelle contact sites.
Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.
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Myristoylated GTP-bound Arf1 recruits AP-1 and stabilizes it in an active conformation, and AP-1:Arf1 self-assembles into a clathrin-independent tubular membrane coat via Arf1 dimer interfaces; HIV-1 Nef hijacks this AP-1:Arf1 coat to sequester MHC-I, and coat-contact residues are conserved across Arf isoforms and AP-1/AP-3/AP-4.
PI is phosphorylated to PI4P by PI4KB at the Golgi membrane
PI4KB binds to ARF1/3:GTP at the Golgi membrane
Formation of a Nef:ARF1:CD4 complex
TGN-lysosomal vesicle coat assembly
trans-Golgi Network Coat Activation
trans-Golgi Network Coat Assembly
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture
trans-Golgi Network Lysosome Vesicle Destined Membrane Coat Assembly
Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane
ARF1:GTP binds Golgin TRIP11
CYTH proteins bind ARF1:GTP
CYTH proteins stimulate ARF1 GTPase activity
PLEKHA3,8 bind PI4P, ARF1
Expression of ADP-ribosylation factor 1
Dissociation of Arf1:GDP, AP-1 Clathrin coated nonameric complex
PLEKHA8 catalyzes transport of GlcCer to plasma membrane
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Glycosphingolipid transport