Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.
Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein.
Global landscape of HIV-human protein complexes.
A proteome-scale map of the human interactome network.
A reference map of the human binary protein interactome.
Kinetic investigation of the polymerase and exonuclease activities of human DNA polymerase ε holoenzyme.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication.
Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis.
Deep research report on POLE4 function
-
POLE4 encodes the smallest accessory subunit of DNA polymerase epsilon, forming stable POLE3-POLE4 heterodimer with histone-fold motifs
"POLE4 is a histone-fold protein, meaning it contains a helix-loop-helix motif structurally analogous to histone proteins. The C-terminal region of POLE4 adopts an H2A-like histone fold, while its partner POLE3 provides an H2B-like histone fold"
-
POLE3-POLE4 heterodimer functions as H3-H4 histone chaperone for replication-coupled chromatin assembly
"Biochemical analyses establish that POLE3-POLE4 is a histone chaperone that promotes tetrasome formation and DNA supercoiling in vitro"
-
Critical for Pol ε complex stability and leading-strand DNA replication fidelity
"POLE4 deficiency in mice destabilizes the entire Pol ε complex, leading to embryonic lethality in inbred strains"
Cyberian deep research on POLE4 function
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin
DNA polymerase alpha:primase binds at the origin
DNA polymerase epsilon binds at the origin