Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
Callosal axon guidance defects in p35(-/-) mice.
Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase.
Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain.
Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction.
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
CDK5 regulates cell adhesion and migration in corneal epithelial cells.
The TGF-beta response to Leishmania chagasi in the absence of IL-12.
Cyclin-dependent kinase 5 phosphorylates signal transducer and activator of transcription 3 and regulates its transcriptional activity.
Cyclin-dependent kinase 5 associated with p39 promotes Munc18-1 phosphorylation and Ca(2+)-dependent exocytosis.
Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription.
Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.
Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons.
Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation.
Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death.
Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK.
CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5.
Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1.
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.
A novel RING finger protein, Znf179, modulates cell cycle exit and neuronal differentiation of P19 embryonal carcinoma cells.
Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation.
Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality.
Calpain 1 or Calpain 2 cleaves Cdk5r1 (p35)
Cdk5:p25 phosphorylates Golga2
Cdk5:p25 phosphorylates lamin A
Cdk5:p25 phosphorylates lamin B1
Cdk5:p25 phosphorylates Prdx1
Cdk5:p25 phosphorylates Prdx2
Cdk5:p25 phosphorylates Jun
Cdk5r1 gene expression is stimulated by Npas4
Cdk5:p25 phosphorylates FOXO3
Falcon deep research synthesis for mouse Cdk5r1
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Cdk5r1/p35 is the non-catalytic regulatory activator that binds and spatially targets CDK5 in neurons.
"Cdk5r1/p35 is not an enzyme; its primary molecular function is to activate and spatially target the serine/threonine kinase CDK5 by direct binding."
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Myristoylated p35 localizes CDK5 activity to membrane-associated neuronal compartments, while calpain-cleaved p25 can redistribute activity to cytoplasmic and nuclear compartments.
"p35 is the obligate regulatory activator of CDK5 and determines where CDK5 acts via myristoylation-dependent membrane targeting."