Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans.
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CLPP-1 encodes a mitochondrial matrix protease homologous to bacterial ClpP
"clpp-1, which encodes a mitochondrial matrix protease homologous to bacterial ClpP"
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clpp-1(RNAi) attenuates UPR-mt signaling and blocks DVE-1 nuclear redistribution
"These events and the downstream UPR(mt) are attenuated in animals with reduced activity of clpp-1"
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CLPP-1 is required for induction of mitochondrial chaperone genes under stress
"These events and the downstream UPR(mt) are attenuated in animals with reduced activity of clpp-1"
Deep research report on clpp-1 function
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CLPP-1 forms homo-oligomeric barrel (two heptameric rings) with ClpX ATPase
"clpp-1 encodes the mitochondrial ClpP protease (EC 3.4.21.92), a serine protease of the S14 family that assembles as a homo-oligomeric barrel (typically two heptameric rings) and partners with the AAA+ ATPase ClpX"
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ATP-dependent matrix proteolysis is CLPP-dependent and inhibited by LY-CMK
"In isolated C. elegans mitochondria, ATP-dependent matrix proteolysis and peptide generation are substantially CLPP-dependent and inhibited by the ClpP inhibitor LY-CMK"
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CLPP-1 generates peptide signals exported via HAF-1 for UPR-mt activation
"HAF-1–dependent peptide export couples CLPP-1–generated peptides to downstream transcription factors"