Selection of an antibiotic-hypersusceptible mutant of Pseudomonas aeruginosa: identification of the GlmR transcriptional regulator.
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GlmR represses transcription of the adjacent glmS homologue.
"We showed that GlmR represses the transcription of the adjacent glmS homologue (PA5549) in P. aeruginosa, possibly affecting the pool of precursors for peptidoglycan and LPS synthesis."
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The glmR mutant is pleiotropic, with filamentous cells, loss of motility and stress sensitivity.
"The drug supersusceptibility of 19A was accompanied by loss of motility, reduced resistance to osmotic and heat shock stress, and impaired growth at low temperatures."
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The mutant has filamentous cells.
"Light microscopy of the mutant strain revealed abnormal morphology characterized by large, filamentous cells."
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Combined Automated Annotation using Multiple IEA Methods