Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
CD40 ligand blocks apoptosis induced by tumor necrosis factor alpha, glucocorticoids, and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4.
Cloning of TRAP, a ligand for CD40 on human T cells.
A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis.
The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells.
Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.
Human CD40-ligand: molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production.
Cleavage of membrane-bound CD40 ligand is not required for inducing B cell proliferation and differentiation.
Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis.
Human native soluble CD40L is a biologically active trimer, processed inside microsomes.
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells.
Interleukin-12 production by human alveolar macrophages is controlled by the autocrine production of interleukin-10.
TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
K63polyUb-cIAP1,2 ubiquitinates TRAF3
Protesomal degradation of K48polyUb-TRAF3
TRAF2:TRAF1:cIAP1,2:TRAF3:NIK regulatory complex binds CD40
CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism.
CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation.
Biological function of CD40 on human endothelial cells: costimulation with CD40 ligand and interleukin-4 selectively induces expression of vascular cell adhesion molecule-1 and P-selectin resulting in preferential adhesion of lymphocytes.