Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency
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RFXAP is a novel subunit of the RFX complex, distinct from RFX5
"RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency"
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RFXAP is mutated in MHC class II deficiency complementation group D
"RFXAP is mutated in the 6.1.6 cell line (group D), as well as in an MHC-II deficiency patient (DA)"
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Complementation with RFXAP restores MHC class II gene expression
"Complementation of the 6.1.6 and DA cell lines by transfection with RFXAP fully restores expression of all endogenous MHC-II genes in vivo"
A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients
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RFX5 and RFXAP are two subunits of the RFX complex
"RFX5 and RFXAP are two subunits of RFX, a multi-protein complex that binds the X box motif of MHC-II promoters"
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RFX complex binds the X box motif of MHC-II promoters
"a multi-protein complex that binds the X box motif of MHC-II promoters"
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RFXANK interaction with RFX5 and RFXAP is essential for DNA binding
"Its interaction with RFX5 and RFXAP is essential for binding of the RFX complex to MHC-II promoters"
Associations and interactions between bare lymphocyte syndrome factors
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Identified specific domains required for RFX complex formation
"The results identified specific domains within each of the three RFX subunits that were necessary for RFX complex formation"
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DNA binding is dependent on RFX complex formation
"DNA binding was dependent on RFX complex formation"
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Transactivation is dependent on a region of RFX5
"transactivation was dependent on a region of RFX5"
Solution structure of the heterotrimeric complex between the interaction domains of RFX5 and RFXAP from the RFX gene regulatory complex
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RFXAP C-terminal domain is unstructured alone but folds upon RFX5 binding
"RFXAP(C) is unstructured in the absence of RFX5(N) but adopts a regular structure in the RFX5(N)(2)-RFXAP(C) complex"
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Two RFX5 molecules and one RFXAP assemble in cytoplasm before nuclear localization
"Two RFX5 molecules and one RFXAP molecule assemble in the cytoplasm prior to nuclear localization"
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RFXAP provides structural scaffolding for complex assembly
"The mammalian immune response is mediated by a heterotetrameric transcriptional control complex, called regulatory factor X (RFX)"
Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
Architecture of the human interactome defines protein communities and disease networks
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome
Multimodal cell maps as a foundation for structural and functional genomics