Gene Ontology annotation through association of InterPro records with GO terms
Combined Automated Annotation using Multiple IEA Methods
A Pro/Ser substitution in nucleoside diphosphate kinase of Drosophila melanogaster (mutation killer of prune) affects stability but not catalytic efficiency of the enzyme.
A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase.
Point mutations in awdKpn which revert the prune/Killer of prune lethal interaction affect conserved residues that are involved in nucleoside diphosphate kinase substrate binding and catalysis.
Post-translational processing of Drosophila nucleoside diphosphate kinase.
Role of AWD/nucleoside diphosphate kinase in Drosophila development.
awd-reference-P08879-uniprot.txt
Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23.
Awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion.
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Awd negatively regulates border cell migration by limiting Pvr and JAK/STAT signalling, and its overexpression suppresses constitutive Pvr and dominant-negative dynamin.
"Here we show that the metastasis suppressor gene homolog Nm23/awd is a negative regulator of border cell migration."
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Overexpression of awd reverts the phenotypes of constitutive Pvr and dominant-negative dynamin in border cells.
"Its overexpression in the border cells results in stalled migration and can revert the phenotype of overexpressing constitutive Pvr or dominant-negative dynamin."
FlyBase gene description for awd (DROME)