GABARAP notes (human, O95166)

Deep research: not run (falcon times out after 600 s in this environment and perplexity-lite is not
installed). Review based on cached publications and the UniProt record.

Key findings

• Form II (PE-conjugated) on autophagosomes PMID:15169837.
• GABARAP subfamily governs autophagosome-lysosome fusion via PLEKHM1 and drives PINK1/Parkin mitophagy PMID:27864321.
• FLCN-FNIP sequestration -> TFEB/TFE3, lysosome biogenesis PMID:34597140; also in STING-induced TFEB activation PMID:39423796.
• ER-phagy receptor UBAC2 PMID:39284914.
• GABA(A) receptor gamma2 and tubulin binding PMID:9892355.
• CUL3-KBTBD6/7 scaffold for TIAM1 degradation PMID:25684205.

Decisions

• 101 protein binding IPI rows: REMOVE (uninformative).
• Core: PE binding (autophagosome maturation/assembly/mitophagy); protein sequestering activity (lysosome biogenesis); GABA receptor binding (neuronal trafficking).
• Death-domain receptor apoptosis (DDX47 co-overexpression) and chemical synaptic transmission: MARK_AS_OVER_ANNOTATED.
• Mouse-derived locations (smooth ER, sperm midpiece, axoneme, Golgi, plasma membrane, lysosome) kept as non-core.