Annotation inferences using phylogenetic trees

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Structure-guided identification of C3d residues essential for its binding to complement receptor 2 (CD21).

Structure of complement receptor 2 in complex with its C3d ligand.

Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein.

The role of complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) in promoting C3 fragment deposition and membrane attack complex formation on normal peripheral human B cells.

The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.

CD21 is a ligand for CD23 and regulates IgE production.

The structure of human CD23 and its interactions with IgE and CD21.

Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.

Epstein Barr virus/complement C3d receptor is an interferon alpha receptor.

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.

A crystal structure of the complex between human complement receptor 2 and its ligand C3d.

Human complement receptor 2 (CR2/CD21) as a receptor for DNA: implications for its roles in the immune response and the pathogenesis of systemic lupus erythematosus (SLE).

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

Genomic organization and polymorphisms of the human C3d/Epstein-Barr virus receptor.

Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes.

Binding of monoclonal antibody to the Epstein Barr virus (EBV)/CR2 receptor induces activation and differentiation of human B lymphocytes.

CD21 and FCRL5 form a receptor complex with robust B-cell activating capacity.

Epstein-Barr virus gp350/220 binding to the B lymphocyte C3d receptor mediates adsorption, capping, and endocytosis.

Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein.

CR2 binds C3d, C3dg, iC3b

CR2:C3d,C3dg,iC3b binds CD19:CD81

Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus.

CR2 source evidence and manual assessment

Functional and antigenic properties of complement receptor type 2, CR2.

Spatially conserved motifs in complement control protein domains determine functionality in regulators of complement activation-family proteins.

The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice.