mut-7 (P34607) review notes

Provenance / process

• Fetched with just fetch-gene worm P34607 --alias mut-7 (Swiss-Prot P34607, 910 aa; same as module).
• Deep research FAILED (falcon timeout; perplexity fallback not configured). No deep-research file was written.

Key findings

• RNase D homolog required for transposon silencing and RNAi PMID:10535732.
• Biochemistry: recombinant MUT-7 is a 3'-5' exoribonuclease on ssRNA PMID:39188014, and MUT7-C binds RNA PMID:39188014.
• Recruitment: PMID:39188014.
• Localization: nucleus and cytosol PMID:15653635; Mutator foci PMID:22713602.
• Required for ERGO-1 26G siRNAs PMID:21245313.

Curation decisions

• IBAs for DSB repair via HR and mitochondrial matrix were removed, and the ssDNA exonuclease IBA was marked as over-annotated. All three come from the EXD2 lineage.
• The Nibbler-based miRNA 3'-end processing ISS rows were marked as over-annotated.
• The bare protein-binding rows (RDE-2/MUT-8) were removed for lack of functional information. The interaction itself is not disputed.
• The physiological substrate of MUT-7 in Mutator foci is unknown. This is a genuine biological gap.