pgs1 (Q9HDW1, SPBP18G5.02) notes

Role: PGP synthase (EC 2.7.8.5), committed step of PG/CL branch; module cdp_dag_phospholipid_synthesis part 6.
Fetch: just fetch-gene SCHPO pgs1 retrieved the correct accession Q9HDW1.

Evidence

• Purified to homogeneity from S. pombe mitochondrial membranes PMID:9468529
• Inner-membrane location, committed step of CL synthesis PMID:9468529; membrane-associated PMID:9468529
• Activity in extracts regulated by growth phase and inositol PMID:1324908
• Reaction and family [UniProt:Q9HDW1 "Belongs to the CDP-alcohol phosphatidyltransferase class-II"]

Decisions

• REMOVE GO:0016024 CDP-diacylglycerol biosynthetic process (EXP, PMID:1324908): pgs1 consumes CDP-DAG; the paper assayed CDP-DG synthase as a separate enzyme.
• MODIFY IC mitochondrial matrix -> mitochondrial inner membrane (abstract of the cited paper states inner membrane). PomBase GO-CAM 67086be200000363 places pgs1 in the matrix.
• mitochondrial membrane organization IC kept as non-core.
• Core: GO:0008444 / GO:0032049 + GO:0006655 / GO:0005743 — same as the S. cerevisiae PGS1 review.