Yml6 is the mitochondrial large-subunit ribosomal protein uL4m. It is a conserved structural component of the mitoribosome that supports mitochondrial translation. The uL4 family contributes to the nascent-polypeptide exit-tunnel constriction, a feature retained in the characterized budding-yeast mitoribosome.
Evidence interpretation: sequence/domain records are used for family placement; AI descriptions and ARBA labels are not independent validation. Family transfer is limited to conserved properties and is identified as inference. Genome-scale localization annotations are retained where consistent with the biology; an abstract does not expose every individual observation. All original annotation rows are preserved.
ProtNLM provenance: pre-release post-processed-2026_02_28k.xml, exact entry and all evidence keys preserved in the source XML/JSON. These current Swiss-Prot entries are absent from the public TrEMBL pilot. Known-function overlap does not establish model training membership. See the function sidecar for atom-by-atom paragraph assessments.
Research provenance: the gene-focused Falcon report was generated concurrently with publication caching. The report was inspected for source leads; the biological decisions above rely on the cited primary records and specified family evidence.
The completed Falcon search has retrieval gaps: its inability to locate target-level localization is not used to override PomBase’s HDA records. Curated genomic-screen observations and the directly inspected papers take precedence over an empty literature-search result.
Target association PMID:34119521: "Mass spectrometry (MS) analysis of Ppr10-copurified proteins revealed that some proteins were specifically detected in the Ppr10-TAP preparation, albeit at low levels. These proteins included mt-SSU proteins (Nam9, Mrps28, Mrp4, and Mrps9), mt-LSU proteins (Aco2-Mrpl49, Mrpl7, and Yml6), SPAC750.08c (a putative NAD-dependent malic enzyme), SPBP4H10.18c (a Schizosaccharomyces specific protein of unknown function), and Anc1 (a mitochondrial ADP/ATP carrier)". This is low-level mass-spectrometry copurification, not a selective Yml6 functional perturbation. The full text of correction PMID:35932618 was checked at Europe PMC; it corrects funding information only.