KEAP1 notes

2026-11-05 ORGANELLES ER batch 2 (endoplasmic reticulum rows)

• Rows: one GO:0005783 row, IEA GO_REF:0000107 (Ensembl projection), located_in; previously KEEP_AS_NON_CORE with an unsupported NFE2L1 rationale.
• Projection source (QuickGO, mouse Q9Z2X8, GO:0005783): a single MGI IDA from PMID:14517290 (fetched; abstract only). The abstract calls the complexes cytoplasmic PMID:14517290. Full text PMC230321 could not be retrieved (PubMed MCP returned no body; NCBI efetch says the publisher does not allow it; Europe PMC returned an error).
• NFE2L1 rationale refuted: PMID:16687406
• UniProt curated location: cytoplasm and nucleus, "Mainly cytoplasmic" [file:human/KEAP1/KEAP1-uniprot.txt]; no ER.
• PubMed search: Keap1 AND ("endoplasmic reticulum membrane" OR "ER membrane") AND localization: 2 hits (16687406 on Nrf1; 42946668, a proteostasis-network survey, no KEAP1 localization result in its abstract), no human KEAP1 ER finding.
• Outcome: KEEP_AS_NON_CORE -> UNDECIDED (only source unreadable). If the source shows only a cytoplasmic pool, MARK_AS_OVER_ANNOTATED; if an ER fraction, KEEP_AS_NON_CORE. Root either way (soluble adaptor).