Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein.
A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation.
eIF2B-related disorders: antenatal onset and involvement of multiple organs.
Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients.
Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways.
The life and death of oligodendrocytes in vanishing white matter disease.
Screening for known mutations in EIF2B genes in a large panel of patients with premature ovarian failure.
Identification of ten novel mutations in patients with eIF2B-related disorders.
An efficient mammalian cell-free translation system supplemented with translation factors.
Next-generation sequencing to generate interactome datasets.
Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
Widespread macromolecular interaction perturbations in human genetic disorders.
Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3.
Formation of eIF2:GDP:eIF2B intermediate
Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells.
Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans.
Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats.
Structural basis for eIF2B inhibition in integrated stress response.
EIF2B2 source-specific evidence and access guide
EIF2B2 literal evidence results
Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter.
Ovarian failure related to eukaryotic initiation factor 2B mutations.
UniProt P49770 EIF2B2 record