Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.
Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding.
Alternative modes of binding of proteins with tandem SH2 domains.
Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells.
Phosphorylation of the N-terminal and C-terminal CD3-epsilon-ITAM tyrosines is differentially regulated in T cells.
A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling.
SPAP2, an Ig family receptor containing both ITIMs and ITAMs.
Calpain II colocalizes with detergent-insoluble rafts on human and Jurkat T-cells.
Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling.
Tyrosine phosphorylation of VHR phosphatase by ZAP-70.
Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains.
ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain.
The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors.
Peptide microarrays for the detection of molecular interactions in cellular signal transduction.
A quantitative protein interaction network for the ErbB receptors using protein microarrays.
Identification of substrates of human protein-tyrosine phosphatase PTPN22.
FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.
ZAP70: a master regulator of adaptive immunity.
The transmembrane adaptor protein SIT inhibits TCR-mediated signaling.
Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.
GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.
Insights into the suppressor of T-cell receptor (TCR) signaling-1 (Sts-1)-mediated regulation of TCR signaling through the use of novel substrate-trapping Sts-1 phosphatase variants.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.
The Us3 Protein of Herpes Simplex Virus 1 Inhibits T Cell Signaling by Confining Linker for Activation of T Cells (LAT) Activation via TRAF6 Protein.
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
ITPRIPL1 binds CD3ε to impede T cell activation and enable tumor immune evasion.
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.
ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.
Essential role for ZAP-70 in both positive and negative selection of thymocytes.
Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance.
Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.
A mutation in zap-70 protein tyrosine kinase results in a selective immunodeficiency.
Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases.
Mechanism of activation for Zap-70 catalytic activity.
Interaction between the SH2 domains of ZAP-70 and the tyrosine-based activation motif 1 sequence of the zeta subunit of the T-cell receptor.
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
ZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulation.
Phosphorylation of ZAP-70 by Lck
Phosphorylation of SLP-76
Phosphorylation of TBSMs in LAT
Phosphorylation of PLC-gamma1
Recruitment of ZAP-70 to phosphorylated ITAMs
Phosphorylation of LAT by p-SYK
Phosphorylation of SLP-76 by p-SYK
Phosphorylation of BTK by p-SYK
Phosphorylation and activation of VAV2/VAV3 by SYK
PTPN22 dephosphorylates ZAP70
RHOH binds effectors at the plasma membrane
STAT3-, DNMT1 and NPM1-ALK-dependent ZAP70 gene silencing
An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor.
ZAP70, too little, too much can lead to autoimmunity.
Cyclophilin A associates with and regulates the activity of ZAP70 in TCR/CD3-stimulated T cells.
Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain.
ZAP-70 augments tonic B-cell receptor and CCR7 signaling in IGHV-unmutated chronic lymphocytic leukemia.
Falcon deep research report for human ZAP70