Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control.
Regulation and localization of the Bloom syndrome protein in response to DNA damage.
Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.
Highlight: BRCA1 and BRCA2 proteins in breast cancer.
Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro.
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex.
WRN interacts physically and functionally with the recombination mediator protein RAD52.
Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.
Ca2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity.
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair.
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair.
BRCA2 BRC motifs bind RAD51-DNA filaments.
MDC1 interacts with Rad51 and facilitates homologous recombination.
Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51.
Interplay between human DNA repair proteins at a unique double-strand break in vivo.
Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis.
XPA versus ERCC1 as chemosensitising agents to cisplatin and mitomycin C in prostate cancer cells: role of ERCC1 in homologous recombination repair.
RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51.
Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats.
Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2.
Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1.
RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination.
Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement.
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.
Resistance to therapy caused by intragenic deletion in BRCA2.
Identification of a novel human Rad51 variant that promotes DNA strand exchange.
The BRC repeats of BRCA2 modulate the DNA-binding selectivity of RAD51.
Streamline proteomic approach for characterizing protein-protein interaction network in a RAD52 protein complex.
Structural transitions within human Rad51 nucleoprotein filaments.
The BRC repeats of human BRCA2 differentially regulate RAD51 binding on single- versus double-stranded DNA to stimulate strand exchange.
Cellular redistribution of Rad51 in response to DNA damage: novel role for Rad51C.
DNA polymerase POLN participates in cross-link repair and homologous recombination.
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.
Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome.
Purified human BRCA2 stimulates RAD51-mediated recombination.
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.
BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping.
The role of the human SWI5-MEI5 complex in homologous recombination repair.
Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1).
A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor.
Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51.
RAD51-associated protein 1 (RAD51AP1) interacts with the meiotic recombinase DMC1 through a conserved motif.
hSWS1·SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair.
Synaptonemal complex protein SYCP3 impairs mitotic recombination by interfering with BRCA2.
Inhibition of homologous recombination by the PCNA-interacting protein PARI.
ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair.
APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1.
RAD51 mutants cause replication defects and chromosomal instability.
Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase.
The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination.
Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.
FIGNL1-containing protein complex is required for efficient homologous recombination repair.
FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells.
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.
PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor.
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.
Systematic identification of molecular links between core and candidate genes in breast cancer.
Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair.
A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination.
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51.
TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.
Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability.
Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex.
The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing.
The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress.
A phosphorylation-deubiquitination cascade regulates the BRCA2-RAD51 axis in homologous recombination.
Cryo-EM structures of human RAD51 recombinase filaments during catalysis of DNA-strand exchange.
Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.
Architecture of the human interactome defines protein communities and disease networks.
RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health.
Discovery of mutations in homologous recombination genes in African-American women with breast cancer.
ATAD5 promotes replication restart by regulating RAD51 and PCNA in response to replication stress.
The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells.
Autism-Associated Vigilin Depletion Impairs DNA Damage Repair.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein.
Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site.
Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin.
FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments.
Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA.
Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA.
The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway.
Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro.
Activities of human recombination protein Rad51.
RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.
Interaction of p53 with the human Rad51 protein.
A novel nucleic acid-binding protein that interacts with human rad51 recombinase.
Regulation of Rad51 function by c-Abl in response to DNA damage.
Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes.
The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment.
XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells.
CHEK1 phosphorylates RAD51
BCDX2 complex stabilizes RAD51 filament
CX3 complex binds D-loop structures
BLM mediates dissolution of double Holliday junction
MUS81:EME1,EME2 cleaves D-loop
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2
Resolution of Holliday junctions cleaved by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
RAD52 promotes single strand annealing at resected DNA DSBs
ERCC1:XPF cleaves flaps generated by SSA
Ligation of DNA and formation of Holliday structures following repair synthesis
RAD51 binds BRCA2 at resected DNA DSBs
Association of RAD51 with RAD52:DNA double-strand break ends
Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)
D-loop dissociation and strand annealing
D-loop extension by DNA polymerases
D-loop formation mediated by PALB2, BRCA2 and RAD51
RAD51 gene expression is stimulated by E2F1 and inhibited by E2F6
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of BRCA1 in PALB2 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in BRCA1 binding
Defective D-loop formation mediated by PALB2, BRCA2 and RAD51 due to loss-of-function of PALB2 in binding to BRCA2/RAD51/RAD51C
BRCA2 mutants with BRC defects or a defect in the C-terminal RAD51 binding site do not bind RAD51
Defective recruitment of BRCA2 and RAD51 due to loss of BRCA2 function in PALB2 binding
ERCC1:XPF binds DNA DSBs with annealed 3' ssDNA overhangs and displaced flaps generated by SSA