Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Association of LKB1 with a WD-repeat protein WDR6 is implicated in cell growth arrest and p27(Kip1) induction.
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WDR6 interacts with LKB1/STK11 via yeast two-hybrid and co-IP
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WDR6 localizes to cytoplasm by immunofluorescence
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WDR6-LKB1 coexpression enhances G1 arrest and p27 induction
Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry.
Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
A proteome-scale map of the human interactome network.
A reference map of the human binary protein interactome.
Intellectual disability-associated gene ftsj1 is responsible for 2'-O-methylation of specific tRNAs.
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WDR6 is human ortholog of yeast Trm734, partners with FTSJ1
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FTSJ1-WDR6 complex catalyzes Gm34 on tRNAPhe(GAA) and position-34 2'-O-methylation on tRNALeu(CAA)
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WDR6 provides tRNA substrate binding while FTSJ1 is catalytic subunit
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m1G37 is prerequisite for Gm34 formation
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wdr6 knockout abolishes Gm34 modification
Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability.
Deep research report on WDR6
Cyberian deep research on WDR6 function