Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Combined Automated Annotation using Multiple IEA Methods.
HSP90 interacts with RAR1 and SGT1 and is essential for RPS2-mediated disease resistance in Arabidopsis.
Arabidopsis cell wall proteome defined using multidimensional protein identification technology.
Isolation and analysis of the expression of two genes for the 81-kilodalton heat-shock proteins from Arabidopsis.
RAR1, a central player in plant immunity, is targeted by Pseudomonas syringae effector AvrB.
A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome.
Arabidopsis ROF1 (FKBP62) modulates thermotolerance by interacting with HSP90.1 and affecting the accumulation of HsfA2-regulated sHSPs.
Structural and functional differences of cytosolic 90-kDa heat-shock proteins (Hsp90s) in Arabidopsis thaliana.
A proteomic strategy for global analysis of plant protein complexes.
Characterization of a Novel DWD protein that participates in heat stress response in Arabidopsis.
Understanding the Physical and Molecular Basis of Stability of Arabidopsis DNA Pol λ under UV-B and High NaCl Stress.
Falcon (Edison Scientific) deep research report: Arabidopsis thaliana HSP90-1 (AT5G52640; UniProt P27323) functional annotation
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"Arabidopsis **HSP90-1** (AtHSP90.1; AT5G52640; UniProt P27323) encodes a **cytosolic Hsp90-family molecular chaperone** that uses an ATP-driven conformational cycle and co-chaperones to **stabilize and mature specific client proteins** in multiple pathways."
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"The best-supported primary functions are (i) **innate immunity**, where AtHSP90.1 forms functionally critical complexes with cochaperones **RAR1** and **SGT1** to support NLR-mediated effector-triggered immunity; and (ii) **proteostasis and developmental plasticity**, where recent work implicates cytosolic HSP90 (including HSP90.1) in **heat acclimation networks** and in **stabilizing plasma-membrane ABCB auxin transporters** through interaction with the immunophilin **TWD1**."
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"Arabidopsis AtHSP90.1 is described with the **canonical three-domain architecture**: an **N-terminal ATPase domain**, a **middle domain** implicated in client interactions, and a **C-terminal dimerization region** containing a conserved **MEEVD motif** that binds many TPR-domain cochaperones."
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"AtHSP90.1 is consistently described as a **cytosolic/cytoplasmic HSP90 isoform**."
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"A landmark Arabidopsis study demonstrated AtHSP90.1 is required for full **RPS2-mediated resistance** and contributes to **RPM1 resistance**, acting with cochaperones **RAR1** and **SGT1**."
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"**athsp90.1** loss-of-function mutants showed **~5–20×** higher bacterial growth by **3 dpi** under RPS2-dependent conditions, with differences reported as significant at **P < 0.05**."
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"*athsp90.1* loss-of-function mutants show no obvious morphology under normal growth but are compromised in effector-triggered immunity; pharmacological HSP90 inhibition similarly impairs HR and resistance. This supports a specialized stress/immune buffering role rather than a strong constitutive developmental defect"
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"Recent work proposes that HSP90 (including **HSP90.1**) contributes to developmental plasticity by stabilizing plasma membrane presence of **ABCB-type auxin transporters**, through interaction with the immunophilin cochaperone **FKBP42/TWD1**."
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"Cytosolic HSP90 participates in a pathway for **post-translational chloroplast preprotein targeting** to the TOC import machinery."
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"the **rof1/rof2 double mutant** accumulates significantly higher levels of many HSPs than WT following acclimation, including **HSP90-1** as a heat-induced “large HSP”."
HSP90.1 primary and phylogenetic scope check (2026-09-20)
Perplexity deep research report on Arabidopsis HSP90.1
HSP90 differentially stabilizes plant ABCB-type auxin transporters on the plasma membrane.
HSP90 regulates temperature-dependent seedling growth in Arabidopsis by stabilizing the auxin co-receptor F-box protein TIR1.
HSP90 functions in the circadian clock through stabilization of the client F-box protein ZEITLUPE.
HSP90s are required for hypocotyl elongation during skotomorphogenesis and thermomorphogenesis via the COP1-ELF3-PIF4 pathway in Arabidopsis.