Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts.
Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity.
INK4 cell cycle inhibitors direct transcriptional inactivation of NF-kappaB.
The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein.
Direct evidence from siRNA-directed "knock down" that p16(INK4a) is required for human fibroblast senescence and for limiting ras-induced epithelial cell proliferation.
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).
Self-assembling protein microarrays.
Contribution of p16INK4a and p21CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53.
A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation.
Functional characterization of human PFTK1 as a cyclin-dependent kinase.
Identification and characterization of a novel protein ISOC2 that interacts with p16INK4a.
A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6.
Proteomic analysis of p16ink4a-binding proteins.
The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a.
p19(ARF) deficiency reduces macrophage and vascular smooth muscle cell apoptosis and aggravates atherosclerosis.
Toward an understanding of the protein interaction network of the human liver.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
The protein interaction landscape of the human CMGC kinase group.
A code for RanGDP binding in ankyrin repeats defines a nuclear import pathway.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor.
Architecture of the human interactome defines protein communities and disease networks.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Growth suppression by p16ink4 requires functional retinoblastoma protein.
Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a.
Association of INK4 family proteins with CDK4/6
Translation of p16INK4A mRNA is inhibited by miR-24
p16INK4A mutants do not bind CDK4
p16INK4A mutants do not bind CDK4,CDK6
MITF-M-dependent expression of CDKN2A gene product 16INK4A
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function.
CDKN2A exact interaction record extract
CDKN2A primary-source access and product evidence
CDKN2A source-linked screen records
CDKN2A protein-product and donor record extract
CDKN2A RNA and four interaction source records