Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence.
Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR.
Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting.
The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site.
Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions.
Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding.
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity.
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation
The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription.
Functional interaction between beta-catenin and FOXO in oxidative stress signaling
Gluconeogenesis: re-evaluating the FOXO1-PGC-1alpha connection
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The original model proposed FOXO1 and PGC-1alpha act synergistically to stimulate gluconeogenic gene expression.
"FOXO1 and the transcriptional co-activator PGC-1alpha act synergistically to stimulate the expression of genes in the gluconeogenesis pathway"
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This report finds FOXO1 is neither required nor sufficient for PGC-1alpha-driven activation of G6Pase reporter expression.
"FOXO1 is neither required nor sufficient for the stimulation of G6Pase-luciferase fusion gene expression by PGC-1alpha"
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The data indicate the FOXO1–PGC-1alpha transcriptional interaction is indirect.
"the transcriptional interaction between FOXO1 and PGC-1alpha is indirect"
APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex.
DBC1 is a negative regulator of SIRT1
Activation of FOXO1 by Cdk1 in cycling cells and postmitotic neurons.
CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor.
GAS6-induced signaling in human endothelial cells is mediated by FOXO1a.
Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification.
C terminus of Hsc70-interacting protein promotes smooth muscle cell proliferation and survival through ubiquitin-mediated degradation of FoxO1.
FoxM1, a critical regulator of oxidative stress during oncogenesis.
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity.
Novel repressor regulates insulin sensitivity through interaction with Foxo1.
Crystallization and preliminary X-ray analysis of a complex of the FOXO1 and Ets1 DNA-binding domains and DNA.
Inhibition of FoxO1 acetylation by INHAT subunit SET/TAF-Iβ induces p21 transcription.
Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels.
Architecture of the human interactome defines protein communities and disease networks.
SCP4 promotes gluconeogenesis through FoxO1/3a dephosphorylation
Cyclophilin A-FoxO1 signaling pathway in endothelial cell apoptosis.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
A central chaperone-like role for 14-3-3 proteins in human cells.
The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3.
Forkhead box O proteins - steering the course of stem cell fate
FOXO transcription factors as mediators of stress adaptation
AKT phosphorylates FOXO transcription factors
AKT phosphorylates FOXO1A
Phosphorylated FOXO1A is excluded from the nucleus
AKT1 E17K mutant phosphorylates forkhead box transcription factors
p-T182 MAPKAPK5 phosphorylates FOXO1
p-S215 FOXO1 binds RAG gene
Expression of STAT3-upregulated nuclear proteins
AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol
14-3-3 proteins bind AKT-phosphorylated FOXO1
FOXO1,FOXO3,(FOXO4) bind FASLG gene promoter
FOXO1,FOXO3,FOXO4 bind CDKN1A gene promoter
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4
FOXO1 binds NPY gene promoter
FOXO1,FOXO3,FOXO4 bind IGFBP1 gene promoter
FOXO1,FOXO3 binds CAV1 gene promoter
FOXO1,FOXO3 bind ABCA6 gene promoter
FOXO1,FOXO3 binds Rbl2 gene
FOXO1,FOXO3 binds Ccng2 gene
FOXO1 binds Fbxo32 gene promoter
FOXO1 and p-2S-Smad2/3:Smad4 bind Mstn gene promoter
FOXO1,FOXO3 and SMAD3 bind Trim63 gene promoter
Deep research report on FOXO1