lpxL (PA3242, HtrB2, Q9HYZ8) review notes

Review session 2026-11-05 (PseudoCAP IBA-seed protocol, tier 2)

Fetched with just fetch-gene PSEAE Q9HYZ8 --alias lpxL; accession matches the worklist. No
deep-research provider used. PMID:26223882 is abstract-only (PubMed MCP returned no body; Europe
PMC full text unavailable for PMC4626592).

Literature

PMID:26223882
PA0011 = htrB1, PA3242 = htrB2. Deletions alter antibiotic and peptide resistance and increase
membrane permeability.
UniProt: HAMAP MF_01942, LpxL/LpxM/LpxP family, cell inner membrane.

Annotation decisions

ACCEPT: GO:0008913 (IDA, IEA), GO:0009245 (IBA, IDA, IEA), GO:0036104, GO:0009103, GO:0005886.
TOO_GENERAL: GO:0016746 (IBA, IEA), GO:0016740, GO:0009247, GO:0016020 (IBA, IEA).
Action counts: ACCEPT 8, TOO_GENERAL 6. No source defects.

PseudoCAP IBA-seed assessment

Shared node PTN004745460 with PA0011 (same paper, same verdict; no node-level defect needed).

PTN node	node term	n_seeds	leaf IBAs	seed annotation (term, evidence, PMID)	verdict	rationale	other seeds	IBD stands without this seed?
PTN004745460	GO:0016746 acyltransferase activity	6	36 (22 taxa)	GO:0008913, IDA, PMID:26223882 (PseudoCAP)	SOUND	Abstract states HtrB2 is responsible for site-specific lipid A acylation; supports the generic node term. Assay type not checked (abstract only).	E. coli LpxL P0ACV0, LpxM P24205, LpxP P0ACV2, M. tuberculosis PatA P9WMB5, PA0011 Q9I7B5	Yes
PTN004745460	GO:0009247 glycolipid biosynthetic process	6	23 (21 taxa)	GO:0009245, IDA, PMID:26223882 (PseudoCAP)	SOUND	Lipid A is a glycolipid; node term is generic enough to cover PIM acylation by PatA.	as above	Yes
PTN000770079	GO:0009245 lipid A biosynthetic process	2	not listed separately	GO:0009245, IDA, PMID:26223882 (PseudoCAP)	SOUND	As above.	E. coli LpxL P0ACV0	Yes