Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome.
Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis.
A novel putative collaborator of p19ARF.
Peptides derived from two dynamically disordered proteins self-assemble into amyloid-like fibrils.
EBV-encoded EBNA-5 associates with P14ARF in extranucleolar inclusions and prolongs the survival of P14ARF-expressing cells.
Immortalization of human mammary epithelial cells is associated with inactivation of the p14ARF-p53 pathway.
p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase.
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.
A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death.
Antiviral action of the tumor suppressor ARF.
A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.
p14ARF interacts with N-Myc and inhibits its transcriptional activity.
The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein.
Activation of p53 by MEG3 non-coding RNA.
A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6.
Tumor suppressor ARF promotes non-classic proteasome-independent polyubiquitination of COMMD1.
Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway.
p14ARF interacts with DAXX: effects on HDM2 and p53.
PTEN regulation by Akt-EGR1-ARF-PTEN axis.
14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF).
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses.
ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress.
Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis.
A novel proapoptotic gene PANO encodes a post-translational modulator of the tumor suppressor p14ARF.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
GLTSCR2 promotes the nucleoplasmic translocation and subsequent degradation of nucleolar ARF.
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.
MDM2 SUMOylates TP53 with SUMO2,3
SUMO E3 ligases SUMOylate target proteins
Translation of p14ARF mRNA is inhibited by miR-24
CDKN2A (p14-ARF) SUMOylates WRN with SUMO1
p14ARF forms a ternary complex with MDM2 and TP53
p14ARF translocates to the nucleus
C1QBP promotes translocation of p14ARF to the mitochondrial matrix
p14ARF mutants do not bind C1QBP
p14ARF mutant does not translocate to the nucleus
p14ARF binds NFE2L2:CREBBP, EP300
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.
CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53.
Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.
TRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome Amplification.
Mitochondrial p32 is a critical mediator of ARF-induced apoptosis.
Amino terminal hydrophobic import signals target the p14(ARF) tumor suppressor to the mitochondria.
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.
Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function.
ARF accession-specific source access and assay evidence
ARF exact source interaction records
ARF SUMO and peptide-assembly source evidence
Official QuickGO record for SUMO ligase regulator activity