raptor (Q9W437) curation notes

Deep research: raptor-deep-research-falcon.md (falcon; the wrapper reported a 600 s timeout but the run completed later). Folded in as an EDIT; its conclusions agree with the review and it is cited in the core function.

Literature journal

• raptor knockdown decreases S6K Thr398 phosphorylation and S6K-driven overgrowth
  PMID:17462592
• raptor depletion causes premature autophagy in dying midgut
  PMID:25882046
• TORC1 negative feedback on Akt
  PMID:20585550
• Muscle raptor knockdown blocks eclosion
  PMID:25866192
• NMJ: raptor knockdown does not phenocopy Tsc2/rictor overgrowth
  PMID:23393158

Curation decisions

• Core: protein-macromolecule adaptor (substrate-recruiting scaffold) in TORC1; TORC1 signaling, positive
  regulation of cell size, negative regulation of macroautophagy (sign checked; same as mTor).
• TOR signaling MODIFY -> TORC1 signaling; regulation of autophagy MODIFY -> negative regulation of macroautophagy.
• NMJ negative regulation and axon-guidance positive regulation UNDECIDED (sign not supported by the
  cached abstracts; same decision as mTor for axon guidance).